The Clinical Research On The Efficiency Of Fluoxetine Combining With Behavior Therapy Of Premature Ejaculation

Objective：In order to study the clinical efficiency of fluoxetine combiningwith behavior therapy of premature ejaculation. Methods：To study on120premature ejaculation cases in our hospital from June2009to June2011, agedfrom23to51, averagely (33.15±6.58) years. And their time of onset wasfrom5weeks to3years, with disease cycle from5weeks to3years, averagely(1.5±0.45) years. Inclusion criteria:①Met the American PsychiatricAssociation "Diagnostic and Statistical Manual of mental disorders4th edition(DSW.IV)"(1994years) recommended by European Assoeiation of urology(EuA) and the premature ejaculation standard of the Intemational Society forSexual Medicine (ISSM), with the ejaculation latency (measured from the penisinto the the vagina to ejaculation time) less than2minutes or ejaculation beforeinserting into the vagina;②Ages beyond18, external genital organs welldeveloped without phimosis or the redundant prepuce otherwise they couldnot be included unless3months later after the operation, and whose erectilefunction must be in good condition and the ones whose erectile percentage inthe morning could reach up to50%as well as the erectile angle could reach60degrees;③Married patients or who had regular sex partner, with stable andregular sex life and had no plan to bear;④The ones who are under otherkinds of treatment must stop the treatment for at least one month;⑤volunteersaccepted the clinical observation and to adhere to complete the clinical trial;⑥ patients combined with infection of urinary system must cure the infection first.Exclusion criteria:①combined erection dysfunction or other sex dysfunction;②spouse had sex dysfunction;③patients had urinary system trauma history,congenital malformation, infection;④patients with abnormity of Routineblood test, urine routine, Blood biochemistry, Sex hormone, Prostatic fluid;⑤SSRIs allergy;⑥combined with organic diseases;⑦Combined withcardiovascular, hepatic, renal and hematopoietic system disease and long termmedication history or psychiatric patients;⑧Abnormal blood pressure,diabetes, spinal cord injury, severe brain of patients with malignant tumor, andpatients after surgery or taken other related drugs;⑨patients who were notAccording to the prescribed medication that is unable to judge the curativeeffect, or incomplete data which affected the observation or safety judgment.Taking the random double-blind method to devide the patients into singlebehavior therapy group (Group A), single fluoxetine therapy group (Group B),and fluoxetine combining with behavior therapy group (Group C). Group A:behavior therapy, together with placebo one time per night within6weeksuninterrupted; group B: taking fluoxetine only,20mg per night within6weeksuninterrupted; group C: behavior therapy, combined with taking fluoxetinetogether of20mg per night within6weeks uninterrupted; There’s no statisticalmeaning to the age and disease cycle of the3groups, it’s comparable. Filling inthe China Index of sexual function for premature ejaculation-5(CIPE-5),which includes ejaculation latency, difficulty of controlling of ejaculation, satisfaction with sexual life of the patients, satisfaction with sexual life of thespouse, the degree of anxiety of the patients’ sexual life. And the item6toitem8of the Questionnaire of the nternational index of erectile function (IIEF),designed by Rosen in1997,(markged0to5points for each item), to evaluatethe satisfaction rate of the patients’ sexual life; the satisfaction rate of thespouse or the sex partners’ sexual life will be taking item10, item13and item14of the IIEF. Observation index: comparing with3groups’ ejaculationlatency, CIPE-5questionnaire score, the patients/spouse/sex partners’satisfaction rate from the IIEF of before and after therapy. Curative judgment:ejaculation latency is extended with2min, or the CIPE-5score>18, werevalid; adverse reactions were also recorded. Results: it’s significant of the3groups’ before and after treatment’s comparison of efficiency, ejaculationlatency, CIPE-5questionnaire score and the patients/spouse/sex partners’satisfaction rate(P<0.05)； comparison of groups: there’s significant differenceof group C (P<0.05), with compared to group A and group B, the resultsindicated that group B’s efficiency is better than group A, but there’s nosignificant difference of the comparison of group A and group B (P>0.5).Conclusions: These findings suggest that fluoxetine combined with Behavior iseffective treatment for premature ejaculation,and its effects will bestrengthened when combined with behavior therapy.