Clinical Study On The Efficacy Of Feiluoning Mixture For Phlegm-heat Obstructing Lung Type AECOPD And The Effect On The Levels Of TNF-α，CRP Of Serum

Objective: To study the clinical efficacy of feiluoning mixture for phlegm-heatobstructing lung type Acute exacerbation of chronic obstructive pulmonarydisease(AECOPD) and the effect on the levels of TNF-α, CRP of serum, and find out therelationship between levels of TNF-α, CRP of serum and Acute exacerbation of chronicobstructive pulmonary disease.Methods:90cases of selected Acute exacerbation of chronic obstructive pulmonarydisease(AECOPD)patients were divided into traditional chinese medicine group （group A30cases), traditional chinese medicine add antibiotics group (group B30cases), antibioticsgroup (group C30cases) three groups, group A using Feiluoning mixture treatment, groupB using Feiluoning mixture add antibiotics treatment, group C for medicine by antibioticstreatment,2weeks after treatment, patients were observed the clinical symptoms and signschange.the blood routine,pulmonary function and artery blood gas analysis change andTNF-α、CRP of the blood changed.Result: the clinical score of three groups are significantly lower than before (P<0.05),group A and group C do not have obvious difference (P>0.05), B group is better than A andC group (P<0.05)，A group is the second; the symptoms efficacy of three groups arecompared, B group is better thanA and C group (P<0.05)，A group is the second;the bloodroutine,pulmonary function and artery blood gas analysis of three groups are all improved,B group is the most obvious，A group is the second；the TNF-α、CRP of the blood are bothlower than before，A and B groups are better than C. Conclusion: Feiluoning mixture can effectively improve the the clinicalsymptoms,signs and the quality of life；Feiluoning mixture can obviously changed theblood routine,pulmonary function and artery blood gas analysis；Feiluoning mixture canlow the expressions of TNF-α,CRP of serum. The TNF-α of serum participate thedevelopment process of acute exacerbation of chronic obstructive pulmonary disease,theCRP of serum reflect the level of the inflammatory response in the acute exacerbation ofchronic obstructive pulmonary disease,determining the changes of them has importantclinical significance for the condition analysis and treatment direction.