| [Objective]To observe the clinical effect of Suhuang Zhike Capsule on cough variant asthma(CVA).[Methods]In the randomized controlled clinical trials,54CVA cases were divided into the treatment group treated by Suhuang Zhike Capsule (n=38), and the control group treatedby Salmeterol and fluticasone pr-opinnate powder inhalant(n=16).The course of treatment was4weeks. The improvement in TCM symptoms, lung function, bronchial challenge test, peripheral eosinophil count and the level of IgE in serum were observed. Data were analyzed using SPSS18.0software. To compare the two groups, the t-test was used for measurement data and the chisqu-retest was used for count data. The rank sum test was used for grad-e data. We considered P values of<0.05to indicate statistical sig-nificance.[Results]In the clinical trials, we studied54patients diagnosed with cough variant asthma aged26-69years. Among them, there were16males (29.63%) and38females (70.37%). In the treatment group, the oldest one was69years old and the youngest was26, the mean age of this group was45.210±13.176years old. While in the control g-roup, the oldest one was60years old and the youngest was26, the average age of this group was48.380±11.673years old. There was not statistical significance in height, weight, body temperature, heart rate, blood pressure, and the frequency of cough, the degree of cough, shortness of breath, throatitch and expectoration between the two groups before treatment (P>0.05). According to the age of the patients, the54cases of CVA were divided into the young group (18-44years old), the middle-aged group (45-59years old) and the older group (60years and above).The proportion of middle-aged group (63%) which the highest, the young group (29.6%) and the old-er group (7.4%) which is the lowest were different. Among them, f-emales were significantly higher than males in45-59aged group. In the part of predisposing factors,66.67%of patients appeared onset or exacerbation of cough due to the changes in ambient temperature, followed by exposure to smell or taste, accounted for59.30%, again for the inhalation of smoke or dust, tired, exogenous and talk. In the part of drug used before the clinical trials,51.85%of the pa-tients had received antibiotic therapy,37.04%of patients had cou-gh or antitussive drug treatment,11.11%had been receiving phlegm drug treatment,11.11%had been receiving leukotriene modifier the-rapy,7.41%had oral traditional Chinese medicine,also7.41%had re-ceived ICS treatment and3.70%of patients had received antihistam-ine drug therapy. Nearly22.22%(12/54) of patients had received two or more kinds of drugs in the treatment.On the total effect after treatment, in the treatment group, the total effective rate was89.5%and the curative rate was47.3%while in the control group, the total effective rate and the curative rate were75.0%and37.5%respectively. And there was no statistically s-ignificant difference between the two groups (P>0.05). On the compr-ehensive effect of TCM symptoms, in the treatment group, the total effective rate was89.5%and the curative rate was36.8%; in the co-ntrol group,the total effective rate was75.0%and the curative rate was37.5%(P>0.05).On the total score of TCM symptoms, the two groups after treatment were significantly decreased (P<0.05) compared w-ith before and they had no significant statistical difference (P>0.05) after the treatment.On the peripheral eosinophil count and the level of IgE in serum, there was no significant statistical differ-r ence (P>0.05) between the two groups of patients before and after the treatment. On the bronchial provocation test, it was positive b- efore the two groups were treated, and some cases of the both groups changed to negative after treatment. In the treatment group, the ne-gative rate was31.6%and it was25.0%in the control group; and no statistically significant difference was found between the two grou-ps (P>0.05). The recovery rate on the frequency of cough, the degree of cough, throat itching, shortness of breath and expectorate-on had no obvious statistical difference (P>0.05). There was significantly decreased about self testing scale score between each group after t-reatment than before (P<0.01), and there wasn’t significant differ-rence between the two groups after treatment (P>0.05).After the tr-eatment, there weren’t adverse events in the test groups except for one case whom suffered from mouth ulcer10days after taking drugs, lasting about1week after the symptoms disappear, but except if not associated with therapeutic drugs in the control group.[Conclusion]Capsule SuHuang ZhiKe has the same therapeutic effect about im-proving the clinical symptoms of patients with CVA compared with sa-lmeterol and fluticasone propionate powder inhalant. Suhuang Zhike capsule which is composed of the traditional Chinese Medicine and without hormones has an obvious therapeutic effect and no obvious t-oxic effects; what’s more it is convenient for taking and is more likely to accept by patients. The method of dispelling wind and rel-ieving spasm has extended new thought of treatment, and Suhuang Zhik e Capsule provides a new choice for the treatment of CVA. |
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