| Baekgroud:Uterine gland myopathy (adenomyosis, AM), also known as the inner temperament palace YiWeiZheng film, to have the growth of the function of the lining of the uterus glands and stroma in myometrium appear and growth within caused by a malignant tumor with the nature of the benign uterine lesions, multiple women bom in growth period, for gynecology diseases and frequently-occurring diseases, the treatment of difficult. In recent years the uterus gland myopathy incidence is rising, seriously affect women’s quality of life, and the increasingly attention by people, so far, the pathogenesis is still unclear. Uterine gland myopathy is the benign disease, but its biological behaviour and malignant tumor have much in common, performance for adhesion, invade, transfer, etc. In recent years the cell apoptosis abnormal cell cycle regulation and control in the tumor proliferation and malignant transformation of behavior has played an important role, and study these genes in the womb and the expression of myopathy glands, discusses the glands of the occurrence and development of myopathy and mechanism are important for uterine gland myopathy and provided the strong theoretical basis.Objective:Through the inspection in the womb Survivin and p16glandular patients with myopathy endometriosis. in the womb and endometrial glands normal endometrium patients with myopathy the expression, the uterus glands in patients with myopathy and normal people compare the expression, discuss the both glands in the womb of the occurrence and development myopathy significance and the relationship between them, so as to provide the basis for clinical treatment of the disease.Methods:the data of shandong university provincial hospital affiliated gynecological2010.3a2011.6from adenomyosis line hysterectomy of patients (30cases), take in the patients with endometrial, ectopic endometrium for the team, and the other for the same period from uterine fibroids do the whole patients underwent hysterectomy normal endometrium (30cases) as control group, all patients were confirmed by histopathological examination. By immunohistochemical S-P method to detect samples in the expression of Survivin and P16and controls.Results:(1) Survivin protein in the uterus gland myopathy ectopic endometrium patients significantly higher than the expression in ectopic endometrium and normal control group (P<0.05). and the normal in ectopic endometrium and the expression no difference (P>0.05).(2) Survivin protein in normal endometrial proliferation period without expression, only in the secretory has a faint expression, and in ectopic neointimal hyperplasia period and secretory all have expressed, but there was not a significant difference (P>0.05).(3) P16protein in normal endometrium significantly higher than the expression of the gland myopathy (P<0.01), and in the glands myopathy in the lining of the expression of ectopic endometrium than (P<0.05).(4) P16protein in normal endometrium, hyperplasia of express below secretory, significant difference (P<0.05), in the muscle gland ill in ectopic ectopic endometrium and, hyperplasia period and secretory express no significant difference (P>0.05).(5) Survivin and the two indexes in p16ectopic endometrium expression of a negative correlation (r=0.416, P<0.05).Conclusion:Not only were Survivin and P16protein’s pressions observed in ectopic and entropic of adenomyosis and normal endometrium without adenomyosis, but also its had a statistically significant difference expression between adenomyosis endometrium and normal endometrium without adenomyosis, but different lining the expression is different,and Significant, suggested they may play an important role in the pathogenesis and the development of adenomyosis. |
