Percutaneous Intervention For Pulmonary Stenosis Due To Takayasu’s Arteritis

Objective:To evaluate the efficacy and safety of percutaneous intervention in treating pulmonary stenosis due to Takayasu’s arteritis.Methods:Consecutive ten patients with Takayasu’s arteritis from January2009to June2011in Fuwai Cardiovascular Disease Hospital, aged17-48(36.2±9.1)years old, had significant pulmonary stenosis and moderate to serious pulmonary hypertension caused by Takayasu’s arteritis, treated in percutaneous pulmonary angioplasty or implementation of stent. In them,5patients accompanied with the involvement of the aorta and its branches, while the others only occurred isolated pulmonary stenosis. After operation, we followed up the patients, including the results of ultrasonic cardiogram, arterial blood gas analysis and some imaging examination and we compared them with the baseline status before intervensions.Results:Percutaneous intervention procedure was successfully performed in13lesions often patients. Among these lesions,9lesions were treated by percutaneous transluminal angioplasty while the others were underwent percutaneous self-explandable stent placement. There were all extremely significant differences in the decrease of the stenosis comparing with the baseline, the broadeness of lesion diameter and decrease of pulmonary artery systolic pressure and mean pulmonary artery pressure after operation(P <0.001).2patients suffered from hemoptysis during perioperation period and recovered completely after active treatments. In a follow-up of5-34(20.4±10.3) months, the pulmonary artery systolic pressure and mean pulmonary arterial pressure were reduced from (92.4±17.2)mmHg to (62.7±14.5)mmHg, from (45.4±9.2)mmHg to (27.1±8.3)mmHg respectively accessed through ultrasonic caridogram, while arterial oxygen saturation was increased from (92.3±3.7)%to (96.8±1.7)(P value for all<0.001).1patient died from pulmonary infection and cardiac shock after1year stopping corticosteroid medcine.Conclusions:Percutaneous intervention for pulmonary stenosis duo to Takayasu’s arteritis was safe and effective. Future researches need more patients to observe and compare randomedly the efficacy of percutaneous intervention with the medical treatment or surgical operation.