| ObjectiveInvestigate the status quo of hyperlipidemia and benign prostatic hyperplasia (BPH),analysis the relationship and the influence of related influencing factors, such as medicine,smoking and drinking, and other metabolic diseases to them in the retired military officersin Shanghai.Material and methodsA total of266elderly retired military officers information in16rest homes for armyleading cadres in Shanghai, containing general situation (age, physical exercise, smokingand drinking), hyperlipidemia and metabolic related materials(hyperlipidemia history, lipidlowering drugs and the levels of total cholesterol, triglyceride, low density lipoproteincholesterol and high density lipoprotein cholesterol), metabolic disease history(hypertension, diabetes, and current level of blood glucose and blood pressure), physicalexamination data, and urology related information(BPH, international prostatic symptomscore, quality of life score) and so on. Make statistical and comparative study of theseabove.All descriptive data are reported as the mean±standard deviation (SD). The dataregarding the percentage were analysed by χ2test. The differences in the mean values wereanalysed by Independent Samples T-test. The influencing factors were analyzed bymultiple linear regression. Significance was defined at the5%level. The SPSS19.0software was used for statistical analysis of the data. The Microsoft Excel2010was usedfor chart drawing.ResultsThe prevalence of hyperlipidemia is63.2%, and the prevalence of BPH is80.5%inthe target population. The prevalence of BPH (81%), IPSS score (9.33±7.394), the volumeof prostate estimated by digital rectal examination, PSA level (1.83±1.881), prevalence ofrelated metabolic deseases (diabetes mellitus25.6%, hypertension72%and obesity82.7%)and smoking and alcohol consumption (Smokers5.4%and drinkers4.2%) inhyperlipidemia group all showed no difference to the nomal lipid group (P>0.05);vesicaltenesmus (1.48±1.597) and intermittent voiding (1.0±1.497) of IPSS score indexeswere both lower than control group (P<0.05). The prevalence of hyperlipidemia (63.6%), prevalence of related metabolic deseases (diabetes mellitus26.2%, hypertension72.4%and obesity79%), PSA level (1.80±1.691), smoking and alcohol consumption (Smokers8.9%and drinkers3.7%), vesicaltenesmus (1.71±1.764) and urination difficulties(0.73±1.434) of IPSS score indexes in BPH group all showed no difference to controlgroup (P>0.05), the other IPSS indexes and QOL score were significantly lower thancontrol group (P<0.05). IPSS score (10.15±7.667) and its all indexes, the volume ofprostate estimated by digital rectal examination, PSA level (1.75±1.492), prevalence ofrelated metabolic deseases (diabetes mellitus25%, hypertension71.3%and obesity81.6%)and alcohol consumption (4.4%) in BPH combined hyperlipidemia group all showed nodifference to pure BPH group (P>0.05), but the rate of smokers (5.9%) was significantlylower than pure BPH group (P=0.039).IPSS score (10.37±7.335) and its all indexes, QOL score (1.97±1.697), the volume ofprostate estimated by digital rectal examination and PSA level (2.28±3.705) in ones withstatins all showed no difference to ones without statins (P>0.05), regardless of in generalpopulation, hyperlipidemia group, BPH group or BPH combined hyperlipidemia group.Aspirin could significantly reduce IPSS score (8.71±6.433) and its indexes such asvesicaltenesmus (1.39±1.571), intermittent voiding (0.93±1.529) and urination difficulties(0.45±1.065), and incease PSA level (2.07±2.154) in both general population and BPHgroup (P<0.05), but hyperlipidemia would weaken the effect. Smoking could reduce QOLscore (1.00±1.309) in BPH combined hyperlipidemia group (P=0.047), but have noinfulence on the volume of prostate estimated by digital rectal examination or IPSS score(11.13±11.655) or PSA level (2.28±3.705)(P>0.05). There were linear relations among thevolume of prostate estimated by digital rectal examination and aspirin and LUTS (IPSSscore)(P=0.000, P=0.001), could establish multi-variable linear regression equation,R=0.223, and the standard determined coefficient were0.071and-0.194. There was nolinear relation between all factors and PSA level (P>0.05).ConclusionsThe prevalence of hyperlipidemia and BPH are both higher than the data of previousstudies. No relationship was seen between hyperlipidemia and BPH, the volume of prostateestimated by digital rectal examination or PSA level. Statins was not related to thediagnostic index of BPH. Aspirin could alleviate LUTS, but hyperlipidemia could weakenthe effect. Smoking and alcohol were not relevant with the occurrence and development of BPH. |
