Study On The Correlation Between Coagulation Function And Chinese Medicine Syndrome Types And Pathological Types In Children With Henoch-Schonlein Purpura Nephritis

Objectives:1.To study the correlation relationship between Chinese Medicine Syndrome Types and pathologic types in children with HSPN.2.To study the correlation relationship between Coagulation function and pathologic types in children with HSPN.3.To study the correlation relationship between Coagulation function and Chinese Medicine Syndrome in children with HSPN.Methods:1. Coagulation function (PT、INR、APTT、Fg、TT) are performed in children with Henoch-Schonlein Purpura Nephritis, whose age are1and18. Then, those patients are separated by zheng differentiation-classification into four kinds of (wind-heat with blood stasis syndrome、 blood-heat with blood stasis syndrome、Yin deficiency with blood stasis syndrome、Qi and Yin deficiency with blood stasis syndrome), and obtained pathological types by means of kidney biopsy.2.100patients with Henoch-Schonlein Purpura Nephritis are separated into wind-heat with blood stasis syndrome group (n=32)、blood-heat with blood stasis syndrome group (n=40)、 Yin deficiency with blood stasis syndrome group (n=27)、 Qi and Yin deficiency with blood stasis syndrome (n=1). The four groups are performed with independent samples group t test based on normal distribution and homogeneity of variance, or performed with two independent samples nonparametric test based on non-normal Distributions or heterogeneity of variance. PT、 INR、APT、Fg、TT are separately compared.At last, the four groups are performed with Kruskal-Wallis test, PT、INR、APTT、Fg、TT are separately compared.3.60patients of all the children with Henoch-Schonlein Purpura Nephritis are divided into type Ⅱ (haplo-mesenteria hyperplasia, n=27) and type Ⅲ (mesenteria hyperplasia with less than50%of kidney glomerulus crescent formation, n=33) in pathologic types. The two goups are performed with independent samples group t test based on normal distribution and homogeneity of variance, or performed with two independent samples nonparametric test based on non-normal Distributions or heterogeneity of variance. PT、INR、APTT、Fg、TT are separately compared.4. The correlativity analysing between Chinese Medicine Syndrome and pathologic types: the two goups are performed with logistic regression.Results:1.Of100patients with Henoch-Schonlein Purpura Nephritis in children, mean age is9.39, no one in the period of infancy (0%),5patients in the period of preschool age (5%),76patients in the period of school age(76%),19patients in the period of puberty(19%).Most of the patients are in the period of school age. Most of the patients are boys (73%)2. Of all the100patients with Henoch-Schonlein Purpura Nephritis in children, wind-heat with blood stasis syndrome32cases,accounts for32%、blood-heat with blood stasis syndrome40cases, accounts for40%、Yin deficiency with blood stasis syndrome27cases, accounts for27%、 Qi and Yin deficiency with blood stasis syndrome1cases, accounts for1%. type Ⅱ (haplo-mesenteria hyperplasia, n=27)27cases, accounts for55%, type Ⅲ (mesenteria hyperplasia with less than50%of kidney glomerulus crescent formation, n=33)33cases, accounts for45%in pathologic types. There is no correlation between Chinese Medicine Syndrome and pathologic types.3.Between Coagulation function and pathologic types in children with HSPN, the APTT of type II in children with Henoch-Schonlein Purpura Nephritis is higher than type III(P<0.05). Still can’t think that PT、INR、Fg、TT of type Ⅱ and type Ⅲ and have the difference. Chinese Medicine Syndrome is correlated with APTT.4. Between Coagulation function and Chinese Medicine Syndrome in children with HSPN, the TT of wind-heat with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis is higher than blood-heat with blood stasis syndrome (P<0.05).The TT of Yin deficiency with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis is higher than blood-heat with blood stasis syndrome (P<0.05). The Fg of blood-heat with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis is higher than wind-heat with blood stasis syndrome (P<0.05).Still can’t think that PT、INR、APTT of Chinese Medicine Syndrome in children with Henoch-Schonlein Purpura Nephritis have the difference.At the same time, can’t think that TT、Fg of wind-heat with blood stasis syndrome and Yin deficiency with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis have the difference. Can’t think that Fg of blood-heat with blood stasis syndrome and Yin deficiency with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis have the difference. Pathologic types is correlated with INR.Conclusions:1.Main of the age onset in children with Henoch-Schonlein Purpura Nephritis is concentrate upon in the period of school age.2. Of Chinese Medicine Syndrome in children with HSPN, most patients manifest as blood-heat with blood stasis syndrome, then, blood-heat with blood stasis syndrome、Yin deficiency with blood stasis syndrome and Qi and Yin deficiency with blood stasis syndrome by turns.Of pathologic types in children with HSPN, most patients manifest as type Ⅱ and type III.At the same time, the sum of type II is more than type Ⅲ.There is no correlation between Chinese Medicine Syndrome and pathologic types.3. Between Coagulation function and Chinese Medicine Syndrome in children with HSPN, the TT of wind-heat with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis is higher than blood-heat with blood stasis syndrome (P<0.05).The TT of Yin deficiency with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis is higher than blood-heat with blood stasis syndrome (P<0.05). The Fg of blood-heat with blood stasis syndrome in children with Henoch-Schonlein Purpura Nephritis is higher than wind-heat with blood stasis syndrome (P<0.05).Chinese Medicine Syndrome is correlated with INR.4. Between Coagulation function and pathologic types in children with HSPN, the APTT of type II in children with Henoch-Schonlein Purpura Nephritis is higher than type III(P<0.05). Still can’t think that PT、INR、Fg、TT of type II and type III and have the difference.Pathologic types is correlated with APTT.5.Most of PT、INR、APTT、Fg、 TT in children with HSPN are in the common range.