Analysis Of Clinical, Pathological Features And TCM Syndrome Types Of Childhood Henoch-schonlein Purpura Nephritis With Diffused Endothelial Cell Proliferaton

Objective:To investigate the clinical and pathological features and TCM syndrome types of ChildhoodHenoch-Schonlein purpura nephritis with diffused endothelial cellproliferation （DEP-HSPN）inchildren.Methods:At present the research about the DEP-HSPN are all focus on the pathological characteristics，And themaximum number of cases reported in the domestic is eight.Through the retrospective analysis thepurpura nephritis’clinical and pathological data of the Henan college of traditional Chinese medicinebetween January2008and May2013,we find the number of Childhood Henoch-Schonlein purpuranephritis with diffused endothelial cellproliferation （DEP-HSPN）is19, Compare the clinical andpathological characteristics between the DEP-HSPN and the Non-DEP-HSPN,to find the influencingfactors of the DEP-HSPN prognosis and the best treatment.Results:(1)19cases DEP-HSPN accounted for3.92%of the485children with renal biopsy HSPN routine atthe same period,10cases (52.63%)of clinical classification are nephrotic syndrome type,9cases(47.37%) of clinical classification are hematuria and proteinuria;(2) The kidney pathology of the19cases DEP-HSPN classification are all IIIb, accompanied by6.38%~36.67%crescent formation;(3) The TCM syndrome types respectively characterized by hot clip stasis blood and Yin deficiencyand blood stasis;(4) After treatment,14cases (73.68%) achieved complete remission,5cases (26.32%) achievedpartial remission，The cases use the strengthen treatment (Methylprednisolone Sodium Succinate forInjection and Cyclophosphamide For Injection with shock therapy) can shorten the duration of thedisappear to the urinary protein（P＜0.05）。(5) To compared the Non-DEP-HSPN of IIIb, DEP–HSPN have high content of protein in the urine, the rate of crescent is same.Conclusions:To compared the Non-DEP-HSPN, the DEP-HSPN’s Clinical manifestations is heave（rP＜0.05）,Renal pathology showed organization more active lesions and less chronic disease（P＜0.05）, Theprognosis is good in the short term,capillaries in hyperplastic lesions is not within the risk factorsinfluencing the prognosis of HSPN（P＞0.05）.