The Clinical Research Of The Pituitary Hormone And Hyponatremia In Patients With Aneurysmal Subarachnoid Hemorrhage

Objective: To investigate the dynamic changes of pituitary hormone of aneurysmalsubarachnoid hemorrhage, analyse hyponatremia pathogenesis and the correlation withHunt-Hess grading and Fisher grading. Methods:49cases of ruptured intracranialaneurysm patients were studied, The venous blood of all these patients were got during1～3days after intracranial aneurysms ruptured, The indexes of14cases were measuredcontinuously, ther blood were got again during7～9days and13～15days afterintracranial aneurysma ruptured. which were sent to the hospital nuclear medicinedepartment for testing; serum electrolytes taken after admission and several times aftersurgery. Results: All the indexes at1～3days,7～9days were Significantly differenteompared with those of the controls, P＜0.05. The indexes at7～9days were mostsignificantly.49cases of aneurysmal subarachnoid hemorrhage, hyponatremia was49.0%,The level of severe hyponatremia incidence of Fisher III-IV grade, Hunt-Hess III-IVgrade was significantly higher than Fisher I-II grade, Hunt-Hess I-II grade, the differencewas significant (P＜0.05); no significant relationship between the aneurysm site and theproportion of hyponatremia; SCVS incidence of hyponatremia group was significantlyhigher than SCVS incidence of normal group. SCVS incidence of Fisher III-IV gradewas significantly higher than the Fisher I-II grade. Conclusion: The changes of pituitaryhormones in patients with aneurysmal subarachnoid hemorrhage was positively correlatedwith the bleeding and the severity of subarachnoid hemorrhage, which reflects thehypothalamic-pituitary extent of damage; hyponatremia is an important indicator to reflectthe severity of subarachnoid hemorrhage. Patients with aneurysmal SAH should becarefully observed and treated as soon as possible. It should be vitals to improve the knowledge about the pathogenesis of hyponatremia following aneurysmal SAH.