Clinical Research On The Curative Effect Of Danshen Chuanxiongqin Injection Against Acute Pancreatitis And Its Affection On Patients’ Serum IL-6、TNF-α And Leptin

Objective:This paper observes and studies the curative effect of Danshen Chuanxiongqin injection on Acute Pancreatitis, and the clinical effect of this injection on patients’serum IL-6, TNF-α and Leptin.Approach:Selected40patients with standard AP. Divided the patients randomly into two groups:the control group and the treated group, each with20people. For the control group, gave Sandostatin, which can suppress the secretion and activity of pancreatin besides the basic therapy. Added0.3mg Sandostatin into250ml physiological saline every12hours. For the treated group, gave Danshen Chuanxiongqin injection on the basis of what the control group do. Added10ml Danshen Chuanxiongqin injection into100ml5%Glucose injection for40drips/min every day. For each group, measured the patients’heights and weights, calculated their weight index BMI and fat percentage; tested the change of levels of IL-6, TNF-α and Leptin in serum before and after the treatment; recorded the recovery time of white blood cells and serum amylase; recorded the pain relief time of abdominal symptom and the average hospital stay time; evaluate the curative powers of different groups.Result: 1. Most of AP are caused by cholelithiasis, engorgement, drinking and hyperlipidemia.2. According to the clinical curative effects, the curative efficiency of the treated group is50%while35%of the control group. Comparing two groups, there is significant difference (P <0.05). The treated group has better curative power than the control group.3. After the treatment, levels of serum IL-6and TNF-α decline significantly (P<0.01); the level of Leptin increases significantly (P<0.01). Levels of serum IL-6and TNF-α of the treated group are significantly lower than that of the control group, while the level of Leptin is significantly higher.4. After the treatment, TCM symptoms scores of the two groups are significant lower (P<0.01); the score of treated group is significantly lower than that of the control group (P<0.01).5. Compared to the control group, the treated group has significantly shorter time for the recovery of white blood cell, serum amylase and shorter time for abdominal pain relief (P<0.05). Average hospital stay time is also significantly shortened in the treated group, with P<0.01.6. The main systemic complications are shock, ARDS and renal failure. The treated group has significantly lower rate of complication occurrence than the control group (P<0.05).7. Compared with overweight or obese men, healthy men without obesity problems have significantly lower BMI and%Fat (P<0.001). Furthermore, the level of Leptin is significantly lower before the treatment (P<0.01). Compared with overweight or obese women, healthy women without obesity also have significantly lower BMI and%Fat (P<0.001), as well as the significant lower Leptin level before the treatment (P<0.01).8. Before the treatment, there is significant correlation between Leptin level and BMI for AP patients (Men r=0.65, Women r0.64, P<0.001); A significant correlation also exists between Leptin level and%Fat (Men r=0.52, Women r=0.53, P<0.001).9. Compared with MAP patients, SAP patients have higher BMI, with a significant p value less than0.05.Conclusion:Danshen Chuanxiongqin injection, combined with western medicine, has significant curative power to treat Acute Pancreatitis. This effect is achieved through suppressing the secretion of inflammation promoting factors and up adjusting the level of inhibitory inflammation factors, thus inhibiting inflammatory responses of pancreas, reducing pancreas tissue damage and generating curative effects. Moreover, there may exist Leptin resistant caused by Leptinemia in the body of obese AP patients, thus affecting prognosis;BMI is related to the extent of AP.