| Objective Henoch Schonlein Purpura (HSP) belongs toimmune complex systemic small blood vessel inflammation. It＇ s causecomplex and some foods is one of the important inducement. Research reportsthe happening of the HSP and food intolerance have certain relevance, andinterleukin5(IL-5)、 IL-10have activity closely relation to the HSP disease.This test through the simply type Henoch Schonlein Purpura patients＇serumfood specificity IgG （immunoglobulin IgG） conventional treatment andconventional cooperate with food intolerance alternate treatment effectobservation, at the same time, detection patients serum IL-5and IL-10level atbefore and after treatment, discussed the mechanism, further prevention andcontrol for the clinical treatment and seek new HSP provide theoretical basis.Methods collecting luzhou medical college affiliated hospital dermatologist inMay2010to June2011simply type Henoch Schonlein Purpura in hospital andclinic patients in102cases. They were texted IgG, then select including62patients with specific IgG positive serum food for experimental research objectpatients and randomly divided into the treatment group and control group in32cases of30cases. Control group accord to the conventional treatment, thetreatment group as the conventional add food intolerance alternate treatment.Food intolerance alternate treatment of specific requirements are as follows: thedetection results is moderate and highly positive food, which are forbitted food for3months. When symptoms disappear completely, then turn into "alternate"treatment;"Alternate": the detection results is mild spositive food,bothintervals of four days before eating the same food; And if the detection resultsis negative food, patients can still continue to eat. Two groups of patientsrespectively have questionnaires after3month and6month. Statistics efficientof treatment group and control group after3months and recurrence rate aftersix months. Its curative effect evaluation standard, reference《blood diseases＇standards of diagnosis and curative》. The result divided into powerfully、effective and invalid. Powerfully: clinical symptoms and signs disappeared andhave a little or no skin eruption who can self healing in3months; Effective:clinical symptoms improved obviously, or recurrence within three months afterhealing; Invalid: symptoms and signs no better after treatment; Recurrences:have symptoms and signs again within4、5、and6months. Efficiency=(powerfully+effective)/all cases×100%, and the recurrence rate=relapsenumber/total number×100%. Two groups of patients respectively test IL-10,IL-5level before and after6months treatment, which of before treatment ofevery group compared with after6months treatment. Results○1The twogroups respectively do questionnaires survey6months and3months.Treatment group lost2cases in follow-up treatment group, the treatment groupresults: investigation after three months:13cases were markedly improved,14effective cases and3invalid cases, the effective rate was90%; Six months afterinvestigation shows,2cases of recurrence, and the recurrence rate is6.67%; The control group results: the treatment results afte3months,11cases weremarkedly improved, effective in8cases, invalid in11, the effective rate was63.33%; Treatment for6months after the results of the survey,10cases ofrecurrence, and the recurrence rate is33.33%; The efficient of two groups after3months and the recurrence rate after6months, statistics are compared for P <0.05, indicating that the treatment group is more effectivly than the controlgroup after treatment and the recurrence rate drop.②The IL-5、IL-10of twogroups of before treatment respectively compared with after6months treatment:treatment group IL-5level2.65±1.66before, after treatment for2.30±1.47,(P<0.05), and the control group therapy IL-5for before2.92±1.57, aftertreatment for2.65±1.30,(P <0.05), The IL-5of two groups of after treatmentis all lower than before treatment, reduce differences are statistically significant;Before the treatment group IL-10level of34.90±19.42, after treatment for31.19±17.53(P <0.05), and the control group serum IL-10before treatmentfor40.02±19.97, after treatment for38.85±18.93,(P <0.05), The IL-10oftwo groups of after treatment is all lower than before treatment, reducedifferences are statistically significant.○3After6months treatment, IL-5,IL-10of the treatment group and control group have statistical comparison,show: treatment group more decrease han that of the control group (P <0.05).Conclusion Simply type Henoch Schonlein Purpura have relevance to foodintolerance. Conventional add food intolerance alternate treatmen is better thanconventional treatment. Its mechanism may relevant to IL-5、IL-10. |
PDF Full Text Request