Homocysteine And The Correlation Of Acute Coronary Syndrome And Intervened Influence

Background:Coronary heart disease because of coronary atherosclerosis or (and) spasm made lumen narrow or totally occluded. It lead to myocardial ischemia or interrupt and produce a cardiomyopathy change. According to the different clinical cases characteristic and the different clinical manifestations, We supposed unstable angina, acute myocardial infarction as the same pathology of different stages of the process, it was named "acute coronary syndrome" name. Acute coronary syndrome is a serious threat to human health and safety of life, its incidence and mortality rate in our country are a significant rise. In recent years, many research acute coronary syndrome of the literature, from the aspects of the investigation. At home and abroad and literature research HCY and more serum hs-CRP is associated with coronary heart disease and acute coronary syndrome, coronary lesions degree relations, also have reported the drugs such as statins and vitamin and so on the influence of both, but few reports in the literature acute coronary syndrome after surgery at PCI, serum HCY and hs-CRP change and what is the significance of clinical. Now for "serum HCY and hs-CRP is associated with acute coronary syndrome relationship and intervened influence" make research, hoping to find more relevant factors in response to intervention and change, guiding clinical diagnosis and treatment of acute coronary syndrome.Objective Explore homocysteine and high sensitivity c-reactive protein and acute coronary syndrome relationship and coronary intervention changes before and after treatment. Use immune method than turbidity, respectively, detection acute coronary syndrome and control group coronary angiography or coronary stents before and after implantation of data changes, the statistical analysis, whether to have meaning. Method (1) case selection and specimens collected:case the standard of the choice for:\"acute coronary syndrome\" admission, complained of chest tightness, chest pain for a typical chest pain or not mainly of patients, the confirmed89cases of coronary angiography. And select the coronary angiography normal the28cases of patients with coronary artery disease. From2010.2to2011.2, each patient follow-up time to postoperative4weeks. All objects are excluded, kidney and liver disease, cerebrovascular disease around vascular disease, gout, diabetes; No acute or chronic infection, surgery, trauma and malignant tumor history. Statistical deviation analysis, the age, sex has no significant difference (P>0.05).(2) Inspection methods:The spirit of the company’s in Dade Behring BN automatic plasma protein analysis system, choose Dade Behring BN experiment reagent, the use of dynamic scattering than turbidity method.89cases were testing an acute coronary syndrome group and28coronary artery of the normal group Hey level and hs-CRP, and70routine coronary stents implantation with72hours after4weeks Hey level, hs-CRP value.Results Acute coronary syndrome group of Hey and hs-CRP content was significantly higher than normal coronary artery (P<0.01). Coronary lesions impact Hey level, its significant difference (P<0.01). Coronary normal person, unstable angina pectoris the, acute myocardial infarction of the group Hey and hs-CRP levels rise in turn (P<0.01). And coronary intervention before and after treatment Hey no significant differences (P>0.05),72hours after the hs-CRP significantly increased, and4weeks after close to normal. The CRP levels in the control group (coronary angiography group) is higher than the postoperation, but the difference was not statistically significant (P>0.05), four weeks later was close to normal.Conclusion Hey level and hs-CRP is cardiovascular disease of important independent risk factor. Hey level and hs-CRP is associated with close to the ACS, positively related, testing their level of change, and can be effectively reflect acute coronary syndrome of the development process and outcome of prevention and treatment for clinical ACS provide reliable basis. Coronary intervention treatment can reduce Hey whether level and role of blood vessels, is yet to be studied further. And hs-CRP can reflect the inflammatory changes. How to reduce PCI postoperative inflammatory reaction, can reduce the incidence of narrow again.