Clinical Study Of Feixuetong Grains In The Treatment Of Prethrombtic State In Patient With AECOPD

Purpose:Observing the effects of Feixuetong grains to AECOPD patients on their clinical symptoms, and the changes of some indexes about inflammatory vascular injury, platelet activation, blood coagulation and fibrinolysis between before and after the treatments. Learn the mechanism of Feixuetong grains on effecting AECOPD prethrombotic state, and the mechanism of improving the clinical effecttion. Get some theoretical and clinical evidence for further medicine development.Methods:Divide40AECOPD patients into two groups-Treat Group(TG) and Control Group(CG) equally. Patients in TG will have additional treatment of Feixuetong grains electuary in the form of two drinks of the same potion a day besides the basic treatments of which patients in CG. The treatment will last two weeks. Recorded clinical symptoms, pulmonary function, arterial blood gas, levels of Fbg、D-D, vWF. ET-1、P-selection、TF、TFPI、t-PA、PAI in peripheral blood of patients both before and after the treatments above TG and CG patients.Result:①The clinical symptoms of all the patients had relieved after treatments (P<0.001). Compared with CG, patients in TG had less coughed and coughing phlegm after treatments (P<0.05),but the score of breathless both CG and TG have no significantly change after treatment (P>0.05).②TG after the treatments had higher FEV1value compared with TG before the treatments and CG after the treatments (P <0.05), but FEV1%pre and FEVi/FVC%have no significantly change between before and after treatment both CG and TG (P>0.05).③Two groups had better arterial btood gas than before treatment (P<0.01), but TG had higher PaO2and lower PaCO2than CG after the treatments (P<0.05).④TG and CG had significantly changes compared with Health Group(HG) at the level of Fbg and D-D (P<0.01, P<0.05) before treatments, TG had lower Fbg and D-D than TG before the treatments,and also had lower Fbg and D-D compared with CG after the treatments (P<0.05).⑤G and CG had significantly changes compared with HG at the level of vWF and ET-1(P <0.01) before treatments. Compared with TG before treatments and CG after treatments, TG after treatments had lower vWF and ET-1levels(P<0.05).⑥-selection levels in both TG and CG were higher than HG before the treatments. While the P-selection levels in TG after treatments became lower than CG (P <0.05).⑦F and TFPI levels in both TG and CG were higher than HG before treatments (P<0.01, P<0.05). TG after treatments had lower TF and TFPI level than before treatments (P<0.05). CG after treatments had lower TF and TFPI level than before treatments, but have no statistical significance (P>0.05).⑧oth TG and CG had a lower t-PA level and a higher PAI level than those in HG before the treatments. Compared with TG before the treatments and CG after the treatments, TG after the treatments had higher t-PA level and lower PAI level (P<0.05).Conclusion:Feixuetong grains can improve clinical symptoms and prethrombotic state of AECOPD patients. And the mechanism probably has some relations with protecting endothelial cell, restraining platelet activity, adjusting coagulation-anticoagulation and fibrinolytic system.