Clinical Research On Prescription Of Expelling Stagnation,Clearing Stomach, Removing Blood Stasis To Interfere In The Syndrome Of Stagnated Heat Of Liver And Stomach With Blood Stasis In Obese Type2Diabetes Mellitus

Purpose:To discuss the understanding of traditional Chinese medicine about obese type2diabetes mellitus by using prescription of expelling stagnation clearing stomach、eliminating blood stasis. To observe the therapeutic efficacy of this method in treating the syndrome of stagnated heat of liver and stomach with blood stasis of obese T2DM and to investigate the mechanism of this method.Methods:A randomized, controlled trial was conducted.60patients with the syndrome of stagnated heat of liver and stomach with blood stasis of obese T2DM were randomly classified into two groups. Besides the intervention of living behavior and western medicine, the patients of the treatment group (n=30) were treated by Chinese medicine whlie the patients of control group (n=30) were not. Three months was a course of treatment. The observed indexes included both change in the clinical symptoms and signs, index about obesity, FBG, PBG, HbAlC, HOMA2-IR, HOMA2-%B, blood-fat, hemorheology and safety indexes. All data were analyzed by the SPSS15.0statistics software.Results:Before treatment, the gender, age, course of disease of the two groups had no differeces.①The total curative effect of treatment group was93.33%, the score of TCM symptom were decreased from20.77±3.43to8.73±2.75; while total curative effect of control group was50,00%, the score of TCM symptom were decreased from20.17±2.29to12.67±2.58. The treatment group gained an advantage over the control group (P<0.05).②The FBG, PBG, HbA1C of the two groups were decreased, compared with pre-treatment there is statistically significant (P<0.01). And the treatment group had an advantage over the control group(P<0.01).③The weight, BMI, WC, HC, WHR of treatment group were decreased, compared with pre-treatment there is statistically significant (P<0.01). The weight, WC, WHR of control group were decreased, compared with pre-treatment there is a remarkable statistically significant (P<0.01). The descent of BMI in control group had a statistically significant compared with pre-treatment(P<0.05) while HC did not(P>0.05). The treatment group had an advantage over the control group in weight, BMI, WC, WHR(P<0.01). The HC of the two groups after treatment had no obvious difference (P>0.05).④The FINS, HOMA2-IR of the two groups were both decreased, the HOMA2-%B of them were elevated, compared with pre-treatment there is statistically significant (P<0.01). And the treatment group had an advantage over the control group(P<0.01).⑤The TG, TC, LDL-C of the treatment group were decreased, the HDL-C of them were elevated, compared with pre-treatment there is a remarkable statistically significant (P<0.01). The TG, TC, LDL-C of the control group were decreased, the HDL-C of them were elevated, compared with pre-treatment there is a statistically significant (P<0.05).And the treatment group had an advantage over the control group(P<0.01).⑥Hemorheology:After treatment, the WHole blood viscosity (highly cuts, middle cuts, lowly cuts5/s, lowly cuts1/s), the blood plasma viscosity of the treatment group decreased, compared with pre-treatment there is a remarkable statistically significant (P<0.01). the WHole blood viscosity (highly cuts, middle cuts, lowly cuts5/s, lowly cuts1/s), the blood plasma viscosity of the control group dropped, compared with pre-treatment there is a remarkable statistically significant in blood viscosity (lowly cuts5/s), the blood plasma viscosity (P<0.01) and a statistically significant in blood viscosity (highly cuts, middle cuts, lowly cuts1/s)(P<0.05). Compared between the two groups, the treated one was better than the other (P<0.01).⑦Safety indicators:Liver and kidney function tests were in the normal range. Both groups were no severe adverse reactions.Conclusion:From the preliminary clinical research, the prescription of expelling stagnation, clearing stomach, eliminating blood stasis combined with metformin can not only improve the clinical symptoms, but also can reduce weight, blood glucose, insulin resistance, lipid, viscosity of blood plasma. It is safe and effective has a broad prospect of application. It is worth studying deeply and developing further.