| BackgroundPrimary liver cancer (Primary hePatocellular carcinoma, PHC) referred to as liver cancer, refers to the occurrence of malignant tumors from the liver cells or intrahepatic bile duct cells, our common one of the top ten malignancies, the prognosis in a variety of solid tumors, the mostone of the poor malignancies, its natural survival of2-6months.2002World Health Organization data show that the global annual increase of about630,000cases of liver cancer and the deaths of about600,000, third leading cause of cancer. China’s annual incidence of about350,000each year about32million people died of the disease, the morbidity and mortality account for the cancer. The prevalence of liver cancer in China is still very serious, the overall level of liver cancer will continue to rise. Variety of modern medicine the treatment of liver cancer, but the overall advantages and disadvantages, liver cancer treatment efficacy is still hard to satisfactory. Since ancient times, the hair of the dog the idea throughout the process of treatment of strange diseases, many masters in some Chinese herbal medicine can not play a good effect when use of toxic drugs, if the application is successfully implemented, each would be good enough. Insects Chinese medicine the most important was considered "sentient flesh and blood products", has go channeling accessible, expelling Blood Circulation, phlegm, and sparse-by found the tick characteristics. Such as the Ming Dynasty Luotian You Health Treasures? health product in addition to "said" Where governance product non-toxic products for the attack can not be."Shen Nong’s Herbal Classic","multi-toxic, non-Jiufu want to get rid of cold and heat evil, broken accumulate more illness, this next by."pointed out that" the accumulation of the syndromes to be "poison" drugs to treat. Yu Biography "Medical Story" is further pointed out that the big drug disease, must be used a big drug of the drug to the attack. Insects rich in traditional Chinese medicine resources, widely used, its role in the treatment of cancer has been preliminary confirmed, these drugs is characterized by the effective dose and toxic dose is very close to the dosage of these drugs in clinical use more than with doctor’s subjective advice and patient requirements, it is necessary to carry out scientific research. Compared to other Chinese traditional medicines, insects Chinese medicine is relatively expensive considering its safety, the validity of the premise, but also consider its economy, in order to maximize patient benefit.Object ivesThe subject of insects medicine scorpion, centipede treatment of liver depression and spleen liver cancer clinical research, and objective evaluation of its clinical efficacy and safety, and pharmacoeconomics compared the increase does not increase the costs of the insects of Chinese medicine in treating liver cancer andeffect, in order to provide a reference for clinical.MethodsRandomized controlled study will meet the diagnostic inclusion criteria,57cases were divided into two30cases of observation group and control group of27cases. The two groups of patients from April2010-April2012, the Guangzhou University of Traditional Chinese Medicine, First Affiliated Hospital oncology inpatients, and control group Si Jun Xiao Yao Tang treatment observation group on the basis of the original parties insects Chinese scorpion, centipede, and addition and subtraction with the card, with a course of three weeks, two groups have given essentially the same basic treatment. Were observed in the clinical score changes before and after treatment, blood analysis, changes in the liver and kidney function, blood coagulation, ECG changes, AFP, AFU, change, and Karnofsky score, body weight changes, drug costs. ResultLiver pain, worms TCM group than in the control group to alleviate the obvious, but no significant difference; mitigation abdominal distension, poor appetite, fatigue, jaundice, loose stools and other symptoms, is basically the same two groups (P>0.05). There was no significant difference, that the insects Chinese medicine and Happy four Jun Tang both to a certain extent, to alleviate a variety of clinical symptoms of advanced liver cancer. The two groups were compared before and after treatment, blood, liver and kidney function, blood clotting function after treatment than before treatment slightly increased, the two groups is relatively more than P>0.05, no significant difference. Insects of Chinese medicine was no significant blood system, liver and kidney toxicity. Alpha-fetoprotein (AFP) change after treatment, both groups before and after treatment than before treatment increased, and P<0.05, statistically significant; the two groups after treatment-L-rock shower sugar former enzyme (AFU) increased over the previous little change (P>0.05), no significant difference. Two groups of drugs can improve patients’quality of life to a certain extent, increase body weight, P>0.05, no significant difference. The two groups showed no significant side effects occurred. Insects Chinese medicine from the efficacy point of view, efficiency is slightly higher than that in the control group, there was no significant difference (P>0.05). Pharmacoeconomic analysis, the cost of two groups-efficacy than those with a significant difference can be seen from Table8, Table9, the21days observation of each patient for drugs higher than the control group, each patient’s drugs396.48yuan in the case of no significant difference in efficiency, the observation group and the control of this-the efficacy of13.08and8.02, respectively, is clearly in the control group treatment program than the observation group economy and reasonable.ConclusionScorpion, centipede to a certain extent, ease the pain of patients with advanced hepatocellular carcinoma in other clinical symptoms, improvement of quality of life as well as liver and kidney function, AFP, AFU, indicators compared with the control group, no significant difference. Increase in insects the Shuganjianpi Endometriosis prescriptions on the basis of traditional Chinese medicine scorpion, centipede, although to some extent, alleviate the pain symptoms in patients with advanced hepatocellular carcinoma, but other clinical symptoms, quality of life improvement and the right of AFP, the the AFU indicators aspects compared with control group, no significant difference. Increase scorpion, centipede group therapy a corresponding increase in cost,21days treatment, observation group each patient’s drugs396.48yuan higher than the control group, each patient’s drugs, so its clinical application requires a combination of economic conditions in patients with may be. |
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