The Clinical Application About Treatment For Lung Cancer By Scorpion, Centipede, Gecko And The Influence Of The Medicine To The Mice Of Lewis Lung Cancer

In the Clinical aspects, through retrospective study, to statistics and analysis the case of the worm medicine of the scorpion, centipede, gecko in lung cancer, and to summarizes the regulation and trait of the medicine in treating lung cancer. In the animal experimental study, to evaluate the effect of restraining the tumour's growth of the scorpion, centipede, gecko in lewis lung cancer, and comparisons the tumor-suppressing rates of this medicine and the high, medium and low different doses.Methods200 cases of patients with lung cancer were collectted as the research object in the First Affiliated Hospital Of Guangzhou University Of Traditional Chinese Medicine, to statistics and analysis the case of the worm medicine and the distribution of different TCM syndrome types of the scorpion, centipede, gecko in lung cancer. At the same time, by copying metastatic murine Lewis lung cancer model, based high, medium and low dose group, chemotherapy group and model group (all 10), to observe the tumor growth in volume, tumor weight.ResultsThere were significant differences of the scorpion, centipede, gecko in the application lung cancer patients, including gecko are most frequently used (84 percent), followed by scorpion (15.5 percent), finally for the centipede (7.5%. percent). According to TCM syndrome differentiations, there was significant differences of the used frequency of scorpion in different syndrome types (P< 0.05), the used frequency of scorpion is the highest in Lung yu phlegm stasis syndrome, and the rest is pixu phlegmy wet syndrome, Yin empty phlegmy heat type, the used Frequency of scorpion is 0 in qi and Yin two empty syndrome. The used frequency of centipede is the same as gecko in different syndrome types (P>0.05). The average taking days and average daily dose of scorpion, centipede, gecko are not all the same with the overall mean(P<0.05),by multiple comparison, the average taking days among the scorpion with the centipede mean same(P> 0.05), between scorpion and gecko, centipede and gecko, there was significant difference (P<0.05). By multiple comparison, the average daily doses are obvious differences (P<0.05).Animal experiment shows that, scorpion,centipede, gecko all have anti-tumor effects, and its anti-tumor effect with the dose of the increase. The high, middle dosage group of scorpion, the high-dosage groups of centipede and high-dosage groups of gecko,the anti-tumor i are the most significant, the effection is as same as cyclophosphamide, these,by comparison between groups, was not statistically significant (P=0.11). The rest of the group, compared with model control group, there is significant difference (P<0.01 or P<0.05), compared with cyclophosphamide group, it's significantly lower than its(P<0.05), between groups,there was not statistically significant (P=0.11).Conclusion The using of gecko is common in lung cancer patients, and free from the influence of TCM syndrome type, the use of the common dose for 5-6g. The using of scorpion in lung cancer patients is not common, the use in patients in the lung yu with phlegm and blood type is more, the rest in turn used more for pixu phlegmy wet, Yin deficiency phlegmy heat, Qi and Yin deficiency of lung cancer patients are for end-stage of malignant tumor, so rarely used such drugs, its often use dose for 6g. The use of centipede in lung cancer patients are least, there are no significant differences in different syndrome types, its often use dose for 3. Animal experiment results showed that the medicines can inhibit the growth of local tumor.