Clinical Observation The Different Length Of Time Of Shuangbai San For External Application On Patients With Acute Cholecystitis

Objecti veUse the Shuangbai San to treat the patients with acute cholecystitis, and determine the different application time on its clinical curative effect, screening of Shuangbai San in adjuvant treatment of acute cholecystitis in the optimum sticking time.MethodsWill meet the inclusion criteria of80patients were randomly divided into control group and treatment group, including20cases of the control group, and60cases of the experimental group. The experimental group according to different application time is evenly divided into4-hour group,7-hour group and10-hour group. The control group was given routine western medicine treatment; in the treatment group based on western medicine treatment was combined with Shuangbai san to the lesion site,7days for a course of treatment. According to different application time, observe the abdominal pain relief time, the symptom and sign score for the third day and the seventh day, changes in heart rate, white blood cell count and transansaminase and renal function before and after the treatment. Seventh day or before discharge review gallbladder B ultrasound. Each group changes before and after treatment use a paired t test, between group compares use the single factor analysis of variance, and categorical variable data use a chi-square test. The purpose is to find the Shuangbai San in treatment of acute cholecystitis in the best stick apply time.ResultsThe study included80patients with acute cholecystitis of non operation treatment of patients, divided into a control group,4-hour group,7-hour group and10-hour group. The gender, age distribution, course of disease and symptom and sign score before treatment between different groups with no statistical difference, is provided with Comparability. Through paired T test, four groups in the changes in heart rate, WBC changes, the abdominal pain relief time, the symptoms and signs score ratings before and after treatment have a statistically significant difference. The third day after treatment, in WBC changes, abdominal pain relief time, the symptom score and signs scoring, there was no statistical difference between control group and4-hour group and there was statistical difference between the7-hour group and10-hour group. The three test groups comparison between any two group, the4-hour group and the7-hour group had statistical difference and so did4-hour group and10-hour group. The7-hour group and10-hour group was not statistically different. There is no statistically significant difference between the groups for the seventh day.ConclusionAll the Shuangbai San groups are obvious better than the control group in the treatment of acute cholecystitis. Shuangbai San associate with antibiotics is obvious better than simple to use antibiotics in the reduce inflammatory response and improve clinical symptoms. Shuangbai San in treatment of acute cholecystitis in the optimum sticking time is7hours. Four groups of security has no significant differences. Obviously, Shuangbai San has more quickly effection of pain reduction.it is worth for clinical use.