| ObjectiveTo analyze the tongue presentation of HIV/AIDS patients, and to explore the relationship between the tongue demonstration and the CD4+T lymph cell values, which can announce the pathology characters of HIV/AIDS patients, and would be helpful for the diagnosis, prognosis and clinical treatment.Methods172cases of HIV/AIDS patients(studied by cross-sectional) and62cases patients(researched by longitudinal) were the outpatients and inpatients of the people’s hospital of Guangzhou eighth(mainly to outpatients), they were both diagnosed with HIV antibody positive by immune imprinting confirmation tests (WB) by the centers for disease control and prevention (CDC) of Guangdong province, the normal people whose tongue pictures were from literature.The tongue pictures were collected by special system Tongue image digital analyzer(ZBOX-1type)applied by Shanghai DaoSheng medical technology Company. The data were collected from8to12am in the outpatient department. The date of partial patients had been collected on many times monthly, the research including several aspects as follows:(1)To analyze tongue characteristics of172cases by cross-sectional observation HIV/AIDS patients different CD4+T lymphocyte count as the tongue of the group, then compared with normal people, to analyze the tongue characteristics of HIV/AIDS patients and to explore the relationship between the tongue demonstration and the different stages of CD4+T lymphocyte count. (2) To divide172cases of HIV/AIDS patients into two groups, one group were the91cases patients who had taken anti—HIV drugs for at least half an year (drug group), the other group were the81cases patients who had not taken any HIV medicine (not drug group), to explore the tongue characteristics of the two groups and the relationship between the tongue demonstration and the different stages of CD4+T lymphocyte count.(3) The tongue demonstration of62cases HIV/AIDS patients were researched by the longitudinal study, observation time point as before given (Highly Active Anti—Retroviral Therapy, HAART) treatment (0month), given HARRT treatment for six month and twelve month, discuss the tongue change between before and after given HAART treatment, to explore the tongue characteristics of HIV/AIDS patients and the relationship between the tongue demonstration and the different stages of CD4+T lymphocyte count.ResultsThe tongue features of172cases of HIV/AIDS patients by cross-sectional study and62cases of HIV/AIDS patients by longitudinal study all showed that: The blood stasis tongue including the ecchymosis tongue and the dull tongue was dominant in HIV/AIDS patients, more HIV/AIDS patients showed fissured tongue and tongue with teeth print, As to tongue coating presentation, more patients showed white, yellow,thick and greasy coating.The patients showed the same relationship between the tongue demonstration and the CD4+T lymphocyte count during the drug group and not drug group of the cross-sectional study and the three follow-up of the longitudinal study, which showed that:the rate of the light red tongue and white coating of patients with CD4+T cell count>350/mm3was found more than those patients with CD4+T cell count<200/mm3(p<0.05), the rate of the dull tongue and fissured tongue and little liver coating of patients with CD4+T lymphocyte count<200/mm3was found more than those patients with CD4+T lymphocyte count>350/mm3(p<0.05), the rate of the greasy coating of patients with CD4+T lymphocyte count between200-350/mm3was found more than both the patients with CD4+T lymphocyte count>350/mm3(p<0.05) and CD4+T lymphocyte count<200/mm3(p<0.05), while the rate of moist coating of the patients with CD4+T lymphocyte count>350/mm3was found more than those patients with CD4+T lymphocyte count≤350/mm3. The longitudinal study also found that, compared with HAART treatment for o month, the tongue demonstration of the HAART treatment for six month and twelve month, the rate of dark red tongue was found increased (p<0.05), the rate of pale tongue was found reduced (p<0.05), while the rate of little liver coating was found increased (p<0.05).ConclusionThrough the analysis of the tongue characteristics of HIV/AIDS patients and the discussion of the relationship between the tongue demonstration and the CD4+T lymphocyte count by the cross-sectional study and longitudinal study which would be helpful for the diagnosis, prognosis and clinical treatment. The state of illness of HIV/AIDS patients was complex, Qi and Yin Deficinecy with obstruction of Blood Stasis and damp evil are more commonly seen TCM pathological changes in HIV/AIDS patients. |
