| Background:Periodontal disease is the disease which happens in the teeth support organization. It is one of the two main kinds of oral diseases, and has a high incidence worldwide. Many of the dental treatments are closely related with periodontal tissue. A number of periodontal tissue diseases are symbols of systemic disease, and are affected by systemic health. Inflammation of periodontal tissue, especially periodontitis may also be dangerous factors for some systemic diseases.The relationship between periodontal disease and diabetes is a long-term study subject. Because of the fundamental pathological changes, such as small vessel disease and low immune response, the resistances of diabetes patients’periodontal tissue to local pathogenic factor drop, and thus aggravate and accelerate the destruction of periodontal support organization.Type II diabetes is the insulin independent diabetes, and due to their own strong genetics and inflammatory immune response background, can cause more complex two-way role relationship between the body’s metabolism level of blood sugar and the periodontal disease.Because of the inconsistency of the diabetes type of study and the nonuniform of periodontal diagnosis index in the early research, it is not easy to compare the research results.In recent years, there are more research work on the relationship between the type1diabetes and periodontal disease, and the research is more focused on the comparative study of the drain of all kinds of liquid ingredients such as ditch:prostaglandin E2, glycosylated hemoglobin A1, IL-1P etc, before and after periodontal treatment.Objective:To evaluate the effect of periodontal health and mechanical therapy on the cytokines IL-6levels in GCF in type II diabetic patients with chronic periodontitis.Methods:A total of58(44-to78-year-old) patients with type II diabetes were recruited, and periodontal examinations including pocket probing depth (PPD), attachment loss (AL), sulcus bleeding index (SBI), plaque index (PLI) were conducted, After that, the randomized controlled and blinded clinical trial with a duration of3weeks,3months and6months respectively, was designed in37patients to compare effects of the GCF volume, concentrations and total amounts of cytokines IL-6between groups of "professional mechanical tooth cleaning PMTC, i.e. coronal scaling"(group II),"periodontal initial therapy"(group I) and "without clinical therapy"(control group).Results:The sample GCF volumes and IL-6level could arise with deeper pocket and more severe gingival inflammation. A significant drop of PD, AL, mBI, GCF volume and total amounts of IL-6were observed compared with baseline in group I after periodontal treatment. The group II had a significant decreasing trends of PD at the third month ((?)=0.36mm, P<0.05), and had a statistical meaning, while other figures showed descending trends but don’t present significances. At the end of study, the group I and II had significant reductions of GCF volume compared with increases of control group (0.96μ1>0.03μ1mm>-0.20μ1, P<0.05).Conclusion:For type II diabetic patients, inflammation of periodontal tissue could affect the GCF volumes and cytokines IL-6levels, and sequential periodontal mechanical therapy could improve the periodontal health and cytokines IL-6levels. |
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