Salvia Injection For Hypertensive Hemorrhage:a Meta-Analysis

Objective:To evaluate the therapeutic efficacy and safety of salvia injection for hypertensive intracerebral hemorrhage(HICH) using Meta-analysis. Methods: Documents were searched both from Pubmed, Medline, Cochrane library, VIP and Wanfang DATA electronically and from other related magazine manually. Randomized controlled trials(RCTs) of salvia injection for HICH were identified. Date of retrieval were up to December2011. Quality assessment and data collection were done independently according to using the Jadad-scale plus allocation concealment.by two reviewers. Meta-analysis was performed with RevMan5.1. Results:245papers were found initially.11RCT were included involving942patients. Meta-analysis showed that:compare to control group, salvia group can increase marked effective rate significantly [RR=1.61,95%CI (1.32,1.96), P<0.01]; decrease neural defects score (NDS) significantly [WMD=-5.85,95%CI(-7.85,-3.85), P<0.01]; reduce the volume of hematoma and cerebral edema significantly,[hematoma WMD=-3.96,95%CI (-4.63,-3.30), P<0.01; cerebral edema WMD=-7.26,95%CI(-7.69,-6.83), P<0.01]. Analysis for subgroup show that:HICH within72h intravenous Salvia lower NDS is better than72h after the onset of administration, the difference was statistically significant, P<0.01. Conclusion:Salvia on HICH has a therapeutic effect, and the efficacy of early treatment may be better. However, due to generally low quality of the included literature, we expect more high-quality, large sample, multi-center randomized controlled clinical trials that provide more definitive evidence for salvia in treating HICH.