A Clinical Analysis On Risk Factors Of Lung Cancer Cases Accompanied With Venous Thromboembolism

Background：Venous thromboembolism (VTE), a common complication in patientswith malignant tumor, has become the second main reason of death caused by malignanttumors. There are two types of VTE, deep vein thrombosis (DVT) and pulmonarythromboembolism (PTE). Lung cancer is one of those malignant tumors with higher risk ofVTE. More and more attention has been paid to cancer-related thrombosis in the past fewdecades, with important progress. However, there is a lack of study on VET accompaniedwith malignant tumor in China. Therefore, it is important to investigate on correlation oflung cancer with VET, in order to pursue practical prevention and treatment.Objective: To investigate the clinical risk factors for lung cancer accompanied withvenous thromboembolism, which may provide the clinical evidence for prevention, diagnosisand treatment of this disease.Methods: We retrospectively reviewed the clinical data of35patients with lung canceramong841with venous thromboembolism between July2009and June2011in ourhosipital.Results：Overall,35patients with lung cancer among841with venous thromboem-bolism were analyzed, the incidence of venous thromboembolism in lung cancer was4.2%.Univariate analysis showed adenocarcinoma, late stage of tumor, comorbidities andincreased D-dimer are risk factors of venous thromboembolism in lung cancer (P <0.05).Multivariate logistic regression showed that adenocarcinoma and increased D-dimer is anindependent risk factor for lung cancer with VTE.7cases of VTE before diagnosed withlung cancer,6cases of VTE diagnosed with lung cancer,11cases of VTE diagnosed withlung cancer in three months,5cases of VTE diagnosed with lung cancer within3-6months,4cases of VTE diagnosed with lung cancer during six months–one year,2cases of VTE oneyear after diagnosis of lung cancer.Conclusion: Patients with adenocarcinoma, late stage of tumor, comorbidities andincreased D-dimer of VTE are risk factors lung cancer patients with VTE, in whichadenocarcinoma and increased D-dime are rare independent risk factor for lung cancer withVTE. The time within3months after the lung cancer diagnosis is the high risk time of venous thromboembolism occurrence. High degree of vigilance, timely diagnosis andtreatment are key to reduce mortality and improve prognosis.