The Clinical Effect Observation Of Yangxueqingnao Granules To Depression After Cerebral Infarction

Objective Observe the clinical effect and safety of yangxueqingnao granules in treating depression after cerebral infarction. Explore the mechanism of the medicine.Methods According to the selected conditions,60patients suffering from depression after cerebral infarction were selected, in which32cases were male and28cases were female. Their ages were from43to85years old, the average was62.92±8.892years old,18cases with history of stroke,12cases living with themselves alone. The60patients were divided into four groups, the experimental group1, experimental group2, experimental group3and the control group. All cases were compared in the fields of gender, age, personal characteristics, history of stroke, living alone or not, education background, profession and HAMD score before treatment, and the differences have no statistical significance, but have comparability. Cases of the control group were patients with depression after cerebral infarction but refusing medicine. Cases of experimental group1were given paroxetine, experimental group2were given Yangxueqingnao Granules, experimental group3were given both paroxetine and Yangxueqingnao Granules. All patients were given eight weeks of oral medications. The content of cortisol, FT3, FT4, TSH in serum and HAMD scores were mensurated before and after treatment. The results were statistical analyzed with SPSS13.0.Results①The general information including gender, age, personal characteristics, history of stroke, living alone or not, education background, and ect., have no statistically significant differences(P>0.05).②The main symptom of depression after cerebral infarction is dizziness, following by depressed mood and sleep disorders.③After treatment the HAMD score of experimental group is more obviously reduced than the control group (P<0.05). The HAMD score of experimental group3reduced the most obviously. The reducing tendencies in experimental group3and experimental group1are both more outstanding than the tendency in experimental group2(P<0.05).④The total effective rate of experimental group1is86.7%(the same as reported in literature basically),73.3%of experimental group2,93.3%of experimental group3. The total effective rate and the constitution rate of deduction in the three groups have no difference by statistical analysis (P>0.05).①The cortisol in serum of experimental group1and experimental group3are reduced obviously than the control group,however experimental group2has no statistical analysis by larger difference to the control group.But no statistical differences in the improvement of thyroid function.⑥All patients have no obvious adverse reaction during treatment.Conclusion Yangxueqingnao Granules have therapeutic effect to depression after cerebral infarction, but weaker than paroxetine (P<0.05). Yangxueqingnao Granules improving depression mood by adjusting the cortisol or thyroid hormone in serum or not need larger sample researching. Two medicine combined together have more stronger effect than paroxetine (P<0.05). Yangxueqingnao Granules can cure the patients with depression after cerebral infarction gently and safely accompanied less side effect as a kind of assistant drug.