Correlative Analysis Between Risk Factors And Type2Diabetic Patients Complicated With Acute Cerebral Infarction

Background and ObjectiveIn2000, there were151million type2diabetes in the world, while after ten years there were285million. According to the current growth rate, there will be500million diabetes throughout the world in2030. In China, the population of diabetic patients account for1/3of the world, while the rate of diabetic patients with cerebral disease is about12.6%.In2010,American Diabetes Association have already take glycated hemoglobin(HbAlc)≥6.5%as one of the diagnostic criteria, so there was more and more attention on it. HbAlc with a certain degree of stability embodies the glycemia level within three monthes. The National Institutes of Health Stroke Scale(NIHSS) was used to evaluate the severity of neurological deficit in acute stroke patients. The aim of the study was to analyze the correlation between the risk factors and type2diabetes with cerebral infarction by reviewing these cases.Objects and methods We retrospectively analysed the type2diabetes with acute cerebral infarction patients (the incidence of stroke in2weeks) and type2diabetes without cerebral infarction (control group),which were admitted to the Second Affiliated Hospital of Zhengzhou University between February2010and December2011. These patients were assessed by Magnetic Resonance Imaging (MRI)or Computed Tomography (CT) to conform the diagnose. Study patients were evaluated for risk factors (sex, age, history of hypertention, glycemia of seven times in a day, biochemical indicator of blood, Fbg, the result of carotid Color Doppler Flow Imaging(CDFI)). The degree of the neurological deficits were assessed by NIHSS.According the standard of NIHSS, the case group was divided into two groups: ischemic minor stroke(NIHSS<3) and ischemic major stroke(NIHSS>3).T test or the rank sum test was used to compare quantitative data.X2test or the rank sum test was used to compare the qualitative data. Multiple factor logistic regression was used to analyze the risk factors. P<0.05was considered statistically significant.ResultsThere were81patients in the case group. Of them,46patients(56.8%) had an ischemic minor stroke(NIHSS<3) and35patients(43.2%) had an ischemic big stroke (NIHSS>3).Among patients with type2diabetes, the level of Fbg and HbAlc in the case group was significantly higher than control group’s(P<0.05).The rate of male and hypertension had sigificantly difference in the two groups(P<0.05).The HbAlc level of ischemic minor stroke was significantly lower the other group(P<0.05). Multiple logistic regression analysis for NIHSS of case group demonstrates that HbAlc and hypertention were signficantly associated with NIHSS(P<0.05).Conclusions1.Ischemic minor stroke is more common in type2diabetic patients with acute cerebral infarction, and its degree of neurological deficits are relatively mild.2.The type2diabetic patients who is male, with hypertention or high Fbg or high HbAlc is prone to have a stroke.3. The higher the HbAlc, the higher the degree of neurological deficits in Type2Diabetic Patients with acute cerebral infarction.4. Hypertension, HbAlc are both dependently risk factors of type2diabetic patients with acute cerebral infarction.