Analysis Of Characteristics And Risk Factors Of Cerebral Microbleeds In Patients With Acute Cerebral Infarction

ObjectThe aim of the study is to explore the epidemiology,risk factors and imaging characteristics of cerebral hemorrhage in patients with acute cerebral infarction,which can provide reference value of individualized treatment plan for patients with acute cerebral infarction,so that it would reduce the occurrence of cerebral hemorrhage.MethodsWe collected patients who met the diagnostic criteria for acute cerebral infarction and were hospitalized in NO.1 hospital of Jilin University Affiliated Hospital department of neurology and its department II from January 2018 to October 2019.A total of 223 patients were included.The general clinical data of the patients was recorded,including: gender,age,The history of smoking,drinking,hypertension,diabetes,previous cerebral infarction,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,fasting blood glucose,uric acid,and NIHSS scores at admission,at the same time,we recorded the number and location of microbleeds in patients.Data analysis was performed using SPSS 21.0.Independent samples t-test ?Nonparametric rank sum test or ?2 test was used for univariate analysis,and logistic regression was used for multivariate analysis.The difference was statistically significant at p <0.05.ResultsThere were 123 patients in CMBs group,88 males and 35 females,with an average age of 63.28 ± 9.28 years.There were 100 patients without CMBs,66 males and 34 females,with an average age of 59.8 ± 9.54 years.The incidence of CMBs was 55.2%.The severity of CMBs was 62 mild patients(50.4%),42 moderate patients(34.1%),and 19 severe patients(15.5%).The distribution of CMBs was 21 cases in the lobar type(17.1%),26 cases in the deep brain tissue type(21.1%),14 cases in the cerebellum or brain stem type(11.4%)and 62 in the mixed type(50.4%).The univariate analysis results were as follows,there was a statistically significant difference in age(t =-2.754,P = 0.006)between the CMBs group and the non-CMBs group.Patients in CMBs group were older than those without CMBs.There were no significant differences in gender,smoking,and drinking history between the two groups.There was a statistically significant difference in the history of previous cerebral infarction between the CMBs group and the non-CMBs group(?2 = 7.646,P = 0.006).The history of previous cerebral infarction in the CMBs group was more common than that in the non-CMBs group.The history of hypertension and diabetes was not statistically significant between the two groups.Low-density lipoprotein cholesterol was statistically significant in the CMBs group and the non-CMBs group.The low-density lipoprotein cholesterol level in the CMBs group was lower than in the non-CMBs group.There were no significant differences in total cholesterol,high-density lipoprotein cholesterol,fasting blood glucose,uric acid,and NIHSS scores at admission between the two group.Logistic multivariate regression analysis showed that elderly patients and previous history of cerebral infarction were independent risk factors for CMBs in patients with acute cerebral infarction(p <0.05).Conclusions1?Patients with mild and mixed cerebral microbleeds were susceptible to acute cerebral infarction.2?Low level of low-density lipoprotein cholesterol was a risk factor for cerebral hemorrhage with acute cerebral infarction.3?Patients with advanced cerebral hemorrhage may be susceptible to acute cerebral infarction.4?Patients who had a history of previous cerebral infarction with cerebral hemorrhage were susceptible to acute cerebral infarction.