Correlation Of Hs-CRP And Other Risk Factors In The Patients Of Acute Cerebral Infarction

Objective:To study the correlation between the level of high-sensitivity C-reactive protein(hs-CRP)and the risk factors associated with acute cerebral infarction(ACI).Provide the clinical basis for prevention and severity assessment of ACI.Methods:From 01 Jan.to 01.Jan.2012,131 in patients with acute cerebral infarction(onset within 3 days)were collected in the Neurology Department of Tianjin First Center Hospital.All cases diagnosed are in line with the revised diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting.Record all cases of admission the serum hs-CRP levels and other laboratory testing indicators and the NIHSS score on admission.hs-CRP determinated by latex enhanced immunoturbidimetric assay,fasting blood glucose determinated by glucose oxidase,lipid determinated by direct measurement,fibrinogen determinated by immune turbidimetric method,homocysteine detected by enzymatic cycling.According to whether the patients are diagnosed as cerebral infarction,all patients are divided into onset group and recurrent group According to gender,all patients are divided into male group and female group.Compare the serum hs-CRP levels of different cerebral infarction groups and normal control group.Other risk factors between group for the first time and recurrent group were analyzed.Serum hs-CRP levels,respectively,are with NIHSS of ACI paitients and other risk factors for the correlation analysis.Results:1.Serum hs-CRP levels in the recurrent group(18.87110.52)and first ever group(12.41±7.56)respectively compared with normal control group,the differece was statistically significant(p<0.05).Recurrent group compared with onset group,the differece was statistically significant(p<0.05).2.Serum hs-CRP levels between the male group(16.07±9.89)and female group(14.94±9.40)of ACI compared,the differece was not statistically significant(p>0.05).Serum hs-CRP levels between the male group(16.07±9.89)and female group(14.94±9.40)of the normal control group compared,the differece was not statistically significant(p>0.05).In male group of acute cerebral infarction,Serum hs-CRP levels compared with male group of normal control group was significantly increased,the difference was statistically significant(p<0.05),In female group of acute cerebral infarction,Serum hs-CRP levels compared with female group of normal control group was significantly increased,the difference also was statistically significant(p<0.05).3.Between groups of patients with different neurological deficit in ACI,serum hs-CRP levels have a significant difference(p<0.05)and the significant correlation between serum hs-CRP levels and NIHSS score(r=0.77,P<0.01).4.In patients with acute cerebral infarction recurrent group,Hcy and LDL-C levels compared with first ever group was significantly increased,the difference was statistically significant(p<0.05),but fasting glucose,TC,TG,Fg,HDL-C in the two groups,there is no significant difference.5.Serum hs-CRP,Hcy and LDL-C was positively correlated(p<0.05)in ACI patients.Conclusion:1.Serum hs-CRP was not found gender differences,and was significantly positively correlated with homocysteine,LDL-Cand the NIHSS score.2.Homocysteine and LDL cholesterol levels increased in patients with recurmet cerebral infarction and may be a risk factor for recurrent cerebral infarction.3.The occurrence and recurrence of ACI are related to non-specific inflammatory response.