| Esophageal cancer accounts for the incidence of malignant tumors in ninth, China is the country with highest esophageal cancel incidence an mortality in the world, according to statistics, more than50%of the world’s esophageal cancer occurred in china. Because of early no obvious symptoms, once definitive diagnosis, more than50%have lymphatic metastasis to distance, thus lost the chance of operation. Therefore, medical therapy should be the first choice in patients with advanced. Traditional Chinese medicine combined with chemotherapy can rise to alleviate pain, improve living quality, prolong the sick role. At the same time, it can reduce the side effects of chemotherapy, assist in tumor cell resistance effect.purposeObserve the clinical efficacy of the treatment of advanced esophageal of Pui Ching sanjie Decoction onesophagus combined with GP regimen,including Changes in tumor lesions,Difficulty swallowing degree,Adverse reaction,Explore the mechanism and significance of thetraining treatment of advanced esophageal cancer in Pui Ching sanjie Decoction onesophagus combined with GP regimen.MethodsThe experiment selects54cases from2005to2011, including30male cases, female24cases, aged45to75years, mean age55.5±11.6years. Karnofsky≥70. No chemotherapy contraindications Checked before chemotherapy. Completely randomized group,27cases in the treatment group,27cases in the control group, which of age, sex have no significant differences in staging. Control group: gemcitabine (hausen Jiangsu Pharmaceutical Company Limited)(1000mg/m2.d), IVGTT, first,8th days; cisplatin (Qilu Pharmaceutical Company Limited production)75mg/(m2.d), IVGTT, first day, a period of21days. Treatment: chemotherapy and oral composition:Pui Ching sanjie Decoction onesophagus (Astragalus30g whole melon20g, Pinellia9g ternata, orange peel10g, codonopsis pilosula30g, acute child30g, tuckahoe30g, zedoary12g,12g P.30g, triquetrous, Salvia30g, hawthornlOg, dangling grass40g, three seven2g (red), powder InulalOg (packet fried), ochre20g.) From each chemotherapy first day oral arc diaphragm soup, a pay daily, Fried take with water, Until the end the cycle of chemotherapy. Two groups of patients were both given protection, the protection of gastric mucosa, antiemetic drugs for symptomatic treatment.OutcomeAfter6courses of treatment, tumor remission as follows:the effective rate of treatment group was48.1%, and control group44.4%, two groups of efficiency (CR+PR) through the chi-square test showed no differences. Treatment groups stability of88.9%, compared to the control group stability above the rate of66.7%, through the chi-square test, P<0.05, there were significant differences. Prompt treatment group can effectively increase the antitumor effect of chemotherapy drug. Comparison of adverse drug reactions:treatment group have myelosuppression, nausea and vomiting, constipation, nerve sensory disorder and a control group of patients were compared, by chi-square test, P<0.05, with significant difference. Tips with Chinese medicine treatment group can effectively control the chemotherapy adverse drug reaction produce. Palliation of dysphagia:treatment group (complete remission rate+part):88.9%; control group (complete remission rate+part):62.9%; through the chi-square test p<0.05, with significant difference. Tips for palliation of dysphagia in treatment group than in the control group have a better effect. ConclusionsThe experimental results show that dissipation diaphragm soup combined with GP regimen has a synergistic effect, which can improve the curative effect, reduce the adverse reaction, improve the quality of life of patients, it’s pointed out that Chinese and Western medicine treatment of esophageal cancer, Have their own strengths,different in indications. Only cooperating each other, preferred treatment regimens, can enhance the efficacy, the principle is reasonable choice and Complementary advantages. |
PDF Full Text Request