Seroepidemiological Survey Of Hepatitis B In Shenzhen Resident Population

Hepatitis B virus (shorted for hepatitis B) was an deadliest of the human infectious disease with a high infection rate and a high proportion of patients who suffering from chronic HBV. It brought great harm to human health and imposed a heavy burden to family and society. Shenzhen has experienced rapid development in30years, and become a city with a population of13million immigrants. It was necessary to make further investigation and research the prevalence of hepatitis B, the effectiveness of hepatitis B immune control.ObjectiveTo learn hepatitis B virus infection rate and its distribution of resident population in Shenzhen City. To explore the impact of population migration to the prevalence of hepatitis B virus. To understand the hepatitis B vaccination and evaluate it immune effects in resident population of Shenzhen City. And to establish the basic information of hepatitis B virus basic material in Shenzhen resident population in order to provide the basis strategies for the development of hepatitis B prevention and control.MethodsField investigation and laboratory test were adopted to describe, analyze and explore the prevention and control measures of hepatitis B (HBV) infection. With multi-stage cluster systematic random sampling method, a total of3771people of1to59years old were recruited from Luohu and Baoan district of Shenzhen city from July to August in2010.5ml blood sample were collected while doing the questionnaire survey. We detected the blood sample for hepatitis B virus surface antigen (HBsAg), hepatitis B virus surface antibody (HBsAb) and hepatitis B virus core antibody (HBcAb) by enzyme-linked immunoadsordent assay (ELISA). Data entry by Epidata3.10software, data collection and analysis by SPSS16.0.ResultsThe positive rate of HBsAg, anti-HBs and anti-HBc and the infection rate of HBV were6.68%,71.92%,37.39%and41.47%respectively in Shenzhen resident population. The infection rate of HBV in females (43.42%) was higher than in males (37.42%), the infection rate of HBsAg increased with age, and the rate was0.16%under5year’s people. Low educated people (junior middle school and below) have higher HBsAg positive rates than high educated people (senior high school and above), however, the anti-HBs positive rates were on the contrary. Hepatitis B vaccination rate was86.50%, and which was decline with the increase of age (t=15.382, P<0.05). The rate of HBsAg positive in Hepatitis B vaccine people was lower than people who did not take Hepatitis B vaccine (χ2=109.26, P<0.01), and higher in the positive rate of anti-HBs (χ2=6.07,P<0.05). The Hepatitis B vaccine immunization rates among young group (≤15years) was93.15%, and the positive rate of HbsAg was higher in those with hepatitis B vaccination than those without(χ2=4.27, P<0.05), but there was no difference about the positive rate of anti-HBs(χ2=2.46, P>0.05). The positive rate of anti-HBs was67.16%among immigrants, which was lower than registered residents (76.61%)(χ2=41.61, P<0.05), and the positive rate of HBsAg in immigrant was7.05%, which was slightly higher than registered residents (6.32%). The positive rate of HBsAg increased with age both in immigrants and registered residents, for children under10, HBsAg positive rate was below2%, and a leaps and bounds increase was found in adults between20and29. The positive rate of HBsAg was much higher for people with low education than those with high education in both group, but for residents with the same educational level.ConclusionsThe infection rates of HBV in Shenzhen permanent population was still high, and health hazard of HBV to a crowd was still serious. since the HBV vaccine immune implement in2002,the crowd HBV vaccine immunization rates was high, the effect of Hepatitis B immune preventive strategies was notable. There was no difference of the HBV infection leval between immigration people and the resdents.