Meta-analysis On Relationship Between Serum UA And Multiple Sclerosis

Objective:To discuss the relationship between serum Uric Acid (UA) levels and multiple sclerosis(MS) patients, with an attempt to provide evidence for the prevention and treatment of MS.Methods:Search the online database including Pubmed, Cochrane library, Embase, Chinese Wanfang Database, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM). In addition, we performed a manual search of many neurology journals. We surveyed studies on the serum UA levels and MS patients and included studies of only case-control design. The methodological quality of the internalized literatures were valuated, screened and heterogeneity tested. A meta-analysis was performed to analysis the data from references using RevMan5.0software.Results:A total of25studies including1521MS cases and1088controls were eligible and abstracted. Result showed that the level of UA in MS was lower than that in controls (SMD=-0.90,95%CI:-1.08～-0.72). The serum UA levels increased in MS patients after corticosteroids pulse therapy when compared to MS without treatment (SMD=-0.96,95%CI:-１.16～-0.75), as well as in relapsing-remitting MS (RRMS) patients with relapse in comparison to RRMS patients with remission (SMD=-0.80,95%CI:-1.42～-0.18).In addition, UA levels were not correlated neither with MRI activity, EDSS nor subtypes of the disease in MS patients. The analytical result of sensitivity proved that the result of meta-analysis was coherent.Conclusions:Serum levels of UA are closely related to MS. Its metabolic abnormality may play a role in the pathological process of MS.The serum levels of UA help to judge the activity of MS and the therapeutic effect of IVMP treatment. Elevating the level of the serum UA may be a anticipant therapy.