Analysis Of Correlation Of HPV Infection And Cervical Neoplasia In Ningbo Region Women

Objective To investigate the cervical lesions and cervical cancer incidence rate, high-risk humanpapilloma virus (HPV) infection rate of married women older than20in Ningbo City. Thecorrelation between factors that cause HPV infection and cervical lesions is further analysed inthis paper.Methods From April2010to May2011,To apply Multistage stratified random cluster samplingmethod, Multistage stratified random cluster sampling method was adopted.8786married womenolder than20in Ningbo City were surveyed from April2010to May2011. Physical examinationin gynecological items and cervical liquid-based cytology was detected. HPV-DNA test of2291random extracted women was assayed.78patients who got ASCUS diagnosis results before werefurther examined by the means of HC-II genomic hybridization capture and cervical pathologybiopsy. Results from the tests were inputted into the database twice using EpiData3．0．reviewed，analyzed，using SPSS17．0．Results1、Abnormal cervical liquid-based cytology detection rate: the current situation of the Ningbo areamarried women older than20women, cervical intraepithelial neoplasia, the town overall detectionrate of0.888%of urban women with cervical abnormalities detection rate of0.82%,towns abnormalcervical cells, detection rate, P>0.05, not statistically significant; rural women with cervical abnormalitiesdetection rate of2.222%, rural regions abnormal cervical cells detection rate (P>0.05), no significant;towns and villages, abnormal cervical cells detection rate, P>0.05, not statistically significant.2、Correlation analysis of the incidence of cervical lesions and cervical liquid-based cytology testresults and colposcopic biopsy results, Cervical liquid-based cytology abnormal women colposcopy biopsy, 37cases diagnosed as cervical intraepithelial neoplasia, cervical biopsy incidence rate of0.421%;48casesof ASCUS cervical biopsy results in40cases of NLMs,7cases of CIN1,1casesCIN2,8were diagnosedtoo low; one cases of the18cases of LSIL colposcopic biopsy results for NLMs,12cases of CIN1,3casesof CIN2,2cases of CIN3, CIN diagnosis in line with rate of66.67%(12/18), the diagnosis is too high, fivecases the diagnosis is too low;12cases of TCT detected as HISL this group with the colposcopic biopsyresults in two cases as of CIN1,7cases of CIN2,3cases of CIN3, of CIN in line withrate of83.33%(10/12), two cases, diagnosis is too low.3、Married women older than20in Ningbo City of reproductive tract HR-HPV infection rate, townsand villages the infection rate was13.27%, of which urban women with cervical HPV infection rate ofabout12.4percent, cities and towns of each region of cervical HR-HPV infection rateP>0.05, notstatistically significant; rural women with cervical HPV infection rate of approximately14.5%rural regionscervical HR-HPV infection rate (P>0.05), no statistical significance; towns and villages of cervicalHR-HPV infection rateP>0.05, not statistically significant.4、HPV infection age distribution:2291Cervical HPV-DNA testing of women, age20to65years ofage. Years old.25to30age group,2cases of2/55(3.6%) positive,30to35age group, the positive19,19/247(7.7%),35to40age group, was positive in69cases of69/418(16.5%)40to45age group,92,92/558(16.5%),45to50age group,51,51/462(11.0%) positive positive positive≥50age group,69cases of69/543(12.7%).<45years old women HPV prevalence increased with age, the infection rate was graduallyincreased;<35-year-old woman HPV infection rate of less than10%;35to44years of HPV infection wassignificantly increased by approximately16.5%;≥45-year-old woman from HPV infection decreased byabout12%.35to44-year-old women with HPV infection rate of women over the age of45, the differencewas statistically significant (χ2=8.442, P=0.004).5、 High-risk types of HPV-DNA infection-related factors: different gestational HPV infectioncomparison, the difference was not statistically significant (χ2=0.991, P=0.804). Whether toolscontraception HPV infection rate, the difference was not statistically significant (χ2=0.598, P=0.439).6、Cervical liquid-based cytology test results and HPV infection results:78patients with abnormalcervical cytology HPV infection were ASCUS.20.08%(10/47), and LSIL66.67%(12/17)of HSIL75.0%(9/11), varying degrees of abnormal cervical cells, HPV infection, the difference was significant (χ2=17.977, P <0.01). Conclusion1、78out of8786(0.888%) married women in Ningbo City were diagnosed cervicaldisease. The incidence of a disease in cervical is0.421%.304out of2291women wereinfected by HPV. No significant difference in HPV infection was found between urben andrural areas. No cervical carcinoma patient was found out in this survey.2、A fraction of cervical liquid-based cytology diagnosis differes from cervicalpathology biopsy diagnosis. Cervical liquid-based cytology combined with cervical pathologybiopsy is a reliable method to make a definite diagnosis of cervical disease.3、HPV infection is prevailed in the women aged from35to45years old. There is nosignificant difference between HPV infection and times of pregnancies, contraceptive method.4、The positive rate of HPV-DNA test is positive correlated with the aberrant intensity ofcervical lesion. HPV-DNA test combined with cervical pathology biopsy and cervicalliquid-based cytology is a reliable method to make a definite diagnosis of cervical disease orcervical carcinoma. It plays a important role in cervical diagnosis.