Significance Of Type2Diabetes’ Glyoxalase I Level In Serum In Early Diabetic Nephropathy

[Objective] To observe the glyoxalase I (GLOI) level in serum of patients withType2diabetes, investigate the significance of GLOI in early diabeticnephropathy (DN).[Methods] Select the patients with type2diabetic who hospitalized in theDepartment of Endocrinology ward of Fujian Medical University Affiliated UnionHospital from March2012to May2012, including34males,32females, agedfrom30to83years old, mean age (61.62±11.50), in which normalalbuminuria group of30patients, average age (62.10±10.82),microalbuminuria in24cases, the average age (58.54±10.71) years old,12cases of massive proteinuria group, the average age (66.58±13.59) years old,each patient is measuered the height, weight,and determine fasting bloodglucose, glycosylated hemoglobin,AGEs,GLOI, and specimened the morningurine to measure morning urine creatinine and morning urine albumin,thencalculate their body mass index (BMI), urinary albumin creatinine ratio (ACR),and compare the different indicators between each group of patients.[Results]The age, body mass index, fasting glucose, glycosylated hemoglobinwere not significant differences between each group of patients, and toexclude the case of other kidney disease, GLOI level in serum showedsignificant difference (P <0.05) in normal albuminuria group, microalbuminuriagroup and massive proteinuria group,further pairwise comparison ofmicroalbuminuria group and massive proteinuria group we found that GLOIlevel of microalbuminuria group and massive proteinuria is lower than normalalbuminuria group (P <0.05), GLOI level of massive proteinuria group is lowerthan microalbuminuria group, but there is no significant difference (P>0.05).AGEs level in serum showed significant difference (P <0.05) in normal albuminuria group, microalbuminuria group and massive proteinuriagroup,further pairwise comparison of microalbuminuria group and massiveproteinuria group we found that AGEs level of microalbuminuria group andmassive proteinuria is higher than normal albuminuria group (P <0.05), AGEslevel of massive proteinuria group is higher than microalbuminuria group, butthere is no significant difference (P>0.05).[Conclusion]GLOI levels declie and AGEs rises in type2diabetic patients withearly diabetic nephropathy,Therefore, GLOI may play an important role in theinhibition of early diabetic nephropathy.