Study On The Diagnostic Effectws And Predicted Mechanism Of The Serum Markers In The Patients With Post-stroke Depression

Objective To explore the diagnostic effects and predicted mechanism of serum markers in patients with post-strok depression(PSD) by mearuring the levels of IGF-1,Leptin,brain-derived neurotrophic factors(BDNF) and inflammatory factors in them.Methods By using Hamilton Rating Scale for Depression(HAMD),46 patients with post-stroke depression were recruited and 50 patients without depression as the control group. Two weeks after the attack of stroke,serum levels of IGF-1,leptin, BDNF,inflammatory factors including intracellular adhesion molecule(ICAM-1) and hs-CRP were measured by enzyme-linked immunosorbent assay(ELISA).Results The serum levels of IGF-1 and leptin in patients with PSD were positively correlated with the HAMD score (r=0.724,p<0.01; r=0.641,p<0.01).The levels of IGF-1 and leptin in patients with PSD were significantly higher than that of the control group(p<0.01). There were no significant differences in the levels of BDNF, ICAM-1 and hs-CRP in the two groups(p>0.05).The levels of IGF-1 and leptin in patients with larger volum of the focus were significantly higher than that of the smaller group (P<0.05).The levels of IGF-1 and leptin in patients with stroke at the anterior part of the brain were significantly higher than that of the posterior group (P<0.01)Conclusion The serum levels of IGF-1 and leptin are found to be associated with post-stroke depression and can be the markers in the prediction and diagnosis of PSD.