The Expression Of BMI-1 And Ki67 In Cervical Carcinoma And Their Significance

Objective To investigate expression of BMI-1 and Ki67 in cervical carcinoma and their correlation with clinicopathological features.Methods 1. Testing the expression of Bmi-1 and Ki67 in 68 cases of cervical cancer and 32 cases of normal tissues by SP immunohistochemical staining.2. Compareing ordered multivariate data by the Kruskal-Wallis test; the correlation of BMI-1 and Ki67 analyzed by Spearman rank correlation. Results 1. The positive rate of Bmi-1 in normal cervical tissue and cervical cancer were 9.38%(3/32) and 85.29% respectively. The difference between the two groups was statistically significant (χ2=23.929, P<0.05). 2. The positive rate of Ki67in normal cervical tissue and cervical cancer were 25.00% (8/24) and 76.47%respectively. The difference between the two groups was statistically significant (χ2=26.662, P<0.001).3. The expression of BMI-1 and Ki67 were positively correlated in cervical carcinoma.4. The expression of BMI-1 and Ki67 were related with degree of differentiation and lymph node metastasis. Conclusion The expression of BMI-1 and Ki67 increased in the Cervical cancer, and a positive correlation between them, while the expression of these two proteins were related with degree of differentiation and lymph node metastasis. It is suggested that BMI-1 and Ki67 involved in the development process of cervical cancer.