The Relationship Study Between The Cmbs And The Clinical Facters Used Swi

Backgroud and PurposeSusceptibility weighted imageing(SWI) have a higher sensitivity than any other sequences to detect the Cerebral Microbleeeds(CMBs).This Study applied SWI sequence to detect the CMBs.Then analysised the relationship between the CMBs and the clinical factors and approached the Risk Factors of the CMBs occurrence.Materials and MethedsCollected 576 cases of cranial magnetic resonance imaging subjects.All subjects were caught the T1WI,T2WI,FLAIR,DWI and SWI sequences of scanning.Of these,346 cases of male,230 cases of female.The age is 21-96 years,the mean age is 57.34±11.77 years.There were 320 cases of the hypertension,105 cases of the diabetes,144 cases of the coronary heart disease,362 cases of the cerebral infarction (lacunar infarction is 117 cases,acute cerebral infarction is 136 cases,old cerebral infarction is 234 cases),18 cases of the cerebral hemorrhageCollected the clinical datas such as the age,height,weight,occupation,blood biochemistry,blood pressure and the histories of hypertension,diabetes,coronary heart disease,smoking,drinking.Statistics the number of the CMBs and the occurrence sites.Analysised the relationship between clinical datas and the occurrence of the CMBs.Approached the Risk Factors of the CMBs occurrence. All cases were divided into CMBs group and no CMBs group.Using the SPSS 13.0 statistical software for statistical analysis.Calculated datas used t-test,Counted datas used chi-square test,Risk Factors analysis used Logistic regression analysis. To P<0.05 was statistically significant.Results119 cases were detected CMBs of 576 subjects.1.The average age of CMBs group is 62.92±12.939years,the no CMBs group is 55.67±14525years.The difference between two groups was statistically significant(P=0.000).1-30years old,31-40years,41-50years,51-60years,61-70years,>70years,the incidence of the CMBs each age group was 9.7%,3.8%,14.5%,20.4%,24.8%,33.3%. The differences were statistically significant (P=0.000).The differences of the occurrence sites of the CMBs in different age groups were statistically significant (P=0.005,0.002,0.049). The highest occurrence in proportion of the CSC aera and the DGM area was the 61-70years age group(33.3%,26/78,35.9%,28/78).The highest occurrence in proportion of the IT area was the above 70years old(30.43%,14/46). 2.The average BMI of the CMBs group is 24.56±3.28㎏/㎡,the no CMBs group is 23.99±3.52㎏ /㎡ .The difference between two groups was no statistically significant(P=0.128).3.The subjects were divided into three categories by following standard:①Physical labour,such as famersand workers.②Both physical and mental, such as teachers, doctors, police, students, businessmen, etc.③Cadres,civil servants, non regular job residents.The proportions of the three job categories of the CMBs group were 75.3%,17.2%,7.5%.The non CMBs group was 77.8%,2.8%,9.4%.The job category constituent ratios of the two groups were non statistically significant(P = 0.451).The CMBs incidences of the three job categories were 21%,17%,25%.The differences were non statistically significant(P=0.461).4.The average systolic blood pressure and the diastolic blood pressure of the CMBs group were 155.20±22.066mmHg and 90.06±16.841mmHg.The average systolic blood pressure and the diastolic blood pressure of the non CMBs group were 143.53±23.056mmHg and 83.79±13.114mmHg.The differences of the systolic blood pressureand the diastolic blood pressure of the two groups were statistically significant(P=0.000,0.000).The CMBs incidences of the light,the midrange and the severe hypertension were 36%,27%,16.2%.The difference was statistically significant (P=0.000). The incidence increased with the severity of hypertension.The CMBs proportions in the CSC area,the DGM area,IT area of the hypertension group were 35%,40%,25%.The hypertension prevalence of the CMBs group was 83%,the no CMBs group was 54.3%.The difference was statistically significant (P=0.000).The time length of the hypertension history of the CMBs group was 8.77±5.36years,the no CMBs group was 7.21±4.523years.The difference between the two time lengths was statistically significant (P=0.000).5.The average triglyceride level of the CMBs group was 1.58±0.88mmol/l.The no CMBs group was 1.53±1.05mmol/l.The difference was non statistically significant(P=0.592). The total cholesterol level of the CMBs group was 4.802±0.609mmol/l.The no CMBs group was 4.890±0.701mmol/l.The difference was non statistically significant(P=0.528). The average fasting blood glucose level of the CMBs group was6.06±2.23mmol/l.The no CMBs group was 5.92±1.57mmol/l,.The difference was non statistically significant(P=0.534).The diabetes prevalence of the CMBs group was 18.9%,the no CMBs group was 21.6%.The difference was non statistically significant (P=0.592).The time length of the diabetes history of the CMBs group was 2.01±508years,the no CMBs group was 2.18±5.08years.The difference between the two time lengths was non statistically significant(P=0.785).Cerebral hemorrhage incidence of the CMBs group was 5.9%,and the no CMBs group hemorrhage incidence was 2.4%.The difference was non statistically significant(P=0.052).4 cases with the cerebral hemorrhage occurred in the DGM area.Of the 4 cases CMBs occurred in the CSC area,the DGM area and the IT area were 2,3,2 cases.Three cases with the cerebral hemorrhage occurred in the IT area.Of the three cases CMBs occurred in the CSC area, the DGM area, the IT areas were 1,1,2 cases.6.The lacunar infarction incidence of the CMBs group was 25.2%,the no CMBs group was 19.0%.The difference was not statistically significant(P=0.136).The acute cerebral infarction and the old infarction incidences of the CMBs group were 35.3% and 61.3%.The no CMBs group was 20.4% and 35.1%.The differences were statistically significant (P=0.001,0.000).The number cases which deteced the CMBs in the CSC area,the DGM area and the IT area of the acute cerebral infarction in the CMBs group were 26,36,19.The DGM area had a highest detection rate(83.7%,36/43),followed by the CSC area(60.4%,26/43) and the IT area(44%,19/43).The number cases which deteced the CMBs in the CSC area,the DGM area and the IT area of the old cerebral infarction in the CMBs group were 53,43,27.The CSC area had a highest detection rate(72.6%,53/73),followed by the DGM area(58.9%,43/73) and the IT area(31.5%,27/43).7.The coronary artery disease prevalence of the CMBs group was 34%,the no CMBs group was 27.5%.The difference was non statistically significant(P=0.227).The time length of the coronary artery disease history of the CMBs group was 5.32±9.57years,the no CMBs group was 3.54±7.54years.The difference between the two time lengths was statistically significant(P=0.044).8.The smoker of the CMBs group was 31.4%,the no CMBs group was 24%.The difference was non statistically significant(P=0.131).The time length of the CMBs group was 9.43±15.36years,the no CMBs group was 5.84±11.58years.The difference between the two time lengths was statistically significant(P=0.009). The Alcohol user of the CMBs group was 34.3%,the no CMBs group was 25.8%.The difference was non statistically significant(P=0.086).The time length of the CMBs group was 9.83±15.00years,the no CMBs group was 6.38±12.21years.The difference between the two time lengths was statistically significant(P=0.014).9.Single factor Logistic regression analysis showed that the CMBs incidence respectively were correlated with the age,the BMI,the blood pressure,the cerebral infarction,the old infarction(P=0.000,0.012,0.000,0.001,0.000;OR=2.078,1.584,1.659, 2.135,2.934;95%C.I.=[1.841-2.916],[1.104-2.273],[1.342-2.050],[1.376-3.313],[1.935-4.450]). Multivariate Logistic regression analysis showed that the occurrence of CMBs were correlated with the history of hypertension,lacunar infarction,old infarction(P=0.000,0.002,0.000;OR=2.924,2.882,3.282;95%C.I=[1.656-5.162],[1.467-5.662],[1.807-5.959])Conclusions We researched the CMBs related questions by SWI techniquel,we summaried followed conclusions finally:1.The CMBs crowd had a higher average age than the non CMBs crowd.The incidence increased with the age growth. 61-70year-olds of the predilection sites were the DGM area and CSC area. Above 70year-olds the predilection sites was CMBs IT area.2.The average BMI had no difference between the CMBs crowd and the non CMBs crowd.The job category constituent ratios of the CMBs crowd and the non crowd were coincidence.The CMBs incidences beween different jobs were not significant deviation. 3.The CMBs crowd had higher blood pressure (systolic and diastolic pressure) than people without CMBs.Different severity of hypertension,the incidence of CMBs was also different:As the severity of hypertension,the CMBs incidence reduced.The hypertensive CMBs people with mild hypertension had a highest proportion.The predilection sites of the Hypertensive CMBs is DGM area,followed by CSC area.The CMBs crowd had higher prevalence of hypertension than people without CMBs.The CMBs crowd of the time lengths of the hypertension history was longer than the non CMBs crowd.4.There were no differences between fasting blood glucose level,triglyceride level and total cholesterol level.5.Cerebral hemorrhage cerebral hemorrhage sites and CMBs had regional relevance.The predilection sites of the Patients with acute cerebral infarction is CMBs DGM area.The old cerebral infarction patients was CSC area.6.The CMBs crowd of the time lengths of the coronary artery disease history were longer than the non CMBs crowd.7.Smoking and drinking may had a certain promote incidence of the CMBs.8.Risk factors analysis Single factor Logistic regression analysis conclusion: With age increased,the risk of CMBs occurrence increasing. The higher the severity of hypertension,the greater the risk of CMBs occurrence As BMI increased,the risk of CMB occurrence increased. Old infarction patients was greater risk of CMBs occurrence than without old infarction. Acute infarction of the crowd was greater risk of CMBs occurrence than those without acute infarction.Multiple factor Logistic regression analysis conclusion: History of hypertension,lacunar infarction,old infarction was independent risk factors of CMBs occurrence. Old infarction was the most risk factors,followed by history of hypertension and lacunar infarction.