The Influence Of Pioglitazone On The Diabetes Nephrosis Urine Micro Albumin And Blood Serum â…£ Collagen

【object】To investigate the change of DN's MAU and CⅣafter the 12-week-long pioglitazone treatment and the relationship of them.【method】Chooses 60 the diabetes nephrosis patients which is hospitalized in endocrine branch and Outpatient treatment. randomly divided into the conventional treatment group (A group) 32 examples, pioglitazone treatment group (B group) 28 examples, and chooses 20 examples healthy patients for the comparison group .The conventional treatment group takes orally decrease-sugar medicine and the insulin treatment, pioglitazone group adds in the conventional treatment foundation with pioglitazone tablet 30mg, one tablet once day, altogether 12 weeks.Taking the record of all patients with the medicine in front of and with the medicine 12-week-long empty-stomach blood sugars (FBG), the systolic pressure (SBP), the diastolic pressure (DBP), saccharify thehemoglobin (HbA1C), and the total cholesterol (TC), triglyceride (TG),the myo- bitter wine (Cr), the urea nitrogen (BUN), MAU, blood serum CⅣ. All measurements material value (x±s) indicated by the mean value(±)standard difference that, around the treatment own comparison uses pairs the t examination, the group the difference uses the variance analysis.【result】(1)Around the conventional treatment group treats the MAU difference non-statistics significance(P>0.05); (2)Around the pioglitazone treatment group treats MAU obviously to drop (P<0.05) (3)Around the conventional treatment group treats the blood serum CⅣ's level have not obviously change (P> 0.05); (4)Around pioglitazone treats the blood serum CⅣ's level have a obvious drop (P<0.05); (5).Around two group of patients treat SBP, DBP, FBG, HbA1C, TG, TC, BUN, the Cr are not obviously different(P> 0.05). (6)The DN patient's MAU and CⅣhas positive relativity(r=0.62,p<0.05)。【conclusion】The DN patient's MAU and CⅣhas positive relativity the DN patient using the pioglitazone may reduce MAU, blood serum CⅣ, proved pioglitazone has the kidney protective function to the DN patient, It has the vital significance to delay DN the occurrence and development.