Research On Detection Of Traumatic Brain Edema By Near-infrared Spectroscopy

Traumatic brain edema is a cerebral pathophysiological response caused by impact or hit of a hard object. Plenty of water accumulates in the extracellular space after the formation of brain edema, which gives rise to larger brain volume, then increasing intracranial pressure, cerebral shift etc., and finally endangers patient's life. Nowadays, clinical brain edema real-time monitoring is mainly utilizing minimally invasive test which is inconvenient for patents'real-time bedside testing. The present study aims to explore a non-invasive brain edema monitoring technology and provide a convenient tool for clinical practice.Present study introduces a noninvasive technical plan based on near infrared spectroscopy for real-time monitoring brain injury. This system achieves non-invasive monitoring of brain edema through real-time collecting cerebral parameters. The main aspects are as follows: (1) the study developed a set of equipment used to continuous and non-invasive monitor brain edema in animals, and accomplished a systematic calibration and experimental verification. (2) Propose an algorithm used to calculate non-invasive blood oxygen parameters. (3) Make use of this system to execute experimental animal models of brain edema and test variation of blood oxygen parameters in models of brain edema. (4) Process and analyze the experimental results of blood models and animal models of brain edema, and obtain variable law of blood oxygen parameters in animal models, eventually initial implement non-invasive monitoring brain edema.The results indicate that non-invasive and real-time monitoring brain edema based on infrared spectroscopy is indeed feasible. We can complete real-time monitoring patients of brain edema using this system, and carry on timely treatment to patients, simultaneously be capable to observe the efficacy evaluation of real-time therapy and conduct real-time assessment. Variety of intracranial pressure reflected from light intensity and changes of blood oxygen parameters would provide significant reference for clinical treatment.The main innovations are as follows: propose a noninvasive technical plan based on near infrared spectroscopy for real-time monitoring brain injury and an algorithm used to non-invasive measure intensity of oxygenated hemoglobin and deoxygenated hemoglobin. Implement a non-invasive measurement of intracranial blood oxygen through this system.