Research On Condition Monitoring Of Traumatic Barin Edma By Near-Infrared Spectroscopy

Traumatic brain edema is caused by brain injury, it is a serious threat to human health. Atpresent, there is not an effective technology to monitor the traumatic brain edema non-invasively. Inthis paper, near infrared spectrum was used to monitor the rat brain edema continuously andnoninvasively. The measurement system of hardware and software was built to study the smallanimals traumatic brain edema.The main work in this paper includs:1. Monte Carlo method was used to simulate the photondistribution in complex brain tissue. The photon’s effective detection depth was calculated from thephoton distribution. The tMCimg software, which was used to simulate the photons’opticaldistribution in complex tissues, was modified to calculate the effective detection depth.2. Multi-layermodels of mouse brain were obtained by the segmentation of MRI images, which were segmentedinto scalp, skull, cerebrospinal fluid, gray and white matters. This segmentation method didn’t dependon templates.3. The effective detection depth of the optical fiber probe in rat traumatic brain edemamodel was studied by phantom experiments. It was shown that effective detection depth in tissue wasless than or equal to half of the distance between source and detector.4. The blood oxygen parametersof rat edema models were got by the NIRs noninvasive monitoring system.5. The system was used tostudy the changes of cerebral edema, the curative effect of mannitol and the changes of oxygenparameters before and after brain edema.Finally, an innovative way based on NIRs to monitor edema model of mouse brain has beenproposed and validated in this paper. The results are important in the future study of brain edema inclinical research.