Effects Of Electroacupuncture And Propofol On Levels Of SOD And IL-1β In Rat Brain With Cerebral Ischemia-reperfusion Injury

Background Cerebrovascular disease is common and frequently occurring nervous system disease, the death rate of which about 10%of all diseases, is currently one of three main causes of death that resulted from human diseases, including cerebral infarction accounts for about 70% of all cerebrovascular diseases. Cerebral ischemia-reperfusion injury is a principal pathomechanism of cerebral infarction. In home and abroad there are many reports on dealing with cerebral infarction by combinating acupuncture with medicine, but there's no study about the effect of electroacupuncture and anesthetics on cerebral ischemia-reperfusion. The objective of this study is to observe the effects of electroacupuncture and propofol on levels of superoxide dismutase (SOD) and interleukin(IL)-iβin rat brain with cerebral ischemia-reperfusion(I-R) injury.Methods I-R rat model was established with four-vessel oclusion method.Forty male SD rats were randomized into groups of A(I-R control), B(I-R plus electroacupuncture) and C(sham operated).The SOD and IL-lβcontents in the brain were measured at 24 h during reperfusion.Results SOD levels in the brain were higher, while IL-1βlevels were lower, in group B than those in groups of C and A at 24 h during reperfusion.Conclusion Electroacupuncture combined with propofol anesthesia can attenuate the cerebral injury in rats underwent I-R.