The Research On Interfering In Hypertensive Early Renal Damage By Compound Yibazhen Capsules

Purpose:Confirmed that compound yibazhen capsules can be further improved on Hypertensive early Renal Damage which on the basis of decreasing blood pressure (using felodipine and enalapril to meet the standards)Ways:where our selection criteria in line with hypertension, a TCM card Yinxuyangkang or hyperactivity,high blood pressure disease limited toⅠ.ⅡPeriod(mild to moderate)Patients,stage II in hypertension as the main observation object,at the age of 18-70 years old, at the same time there is urine MALB>13.4mg/L and/or urine B 2-MG≥0.227mg/L in urine NAG≥17.8U/g and some hospital out-Patient cases, as the observation of objects, were randomly divided into treatment group (20cases) and control group (20cases). Treatment group and control group using the same basic treatment, such as smoking cessation, alcohol, take Part in physical exercise, diet, light, combined hyperlipidemia, hyperuricemia and other treatment when symptomatic. Totally 40 cases used felodipine and enalapril to make blood pressure≤140/90mmHg, in addition, the treatment group were given compound yibazhen capsules,6 Weeks for a course of treatment, compound yibazhen capsules was Composed by sticktight, polygonum multiform, fructus corni. Observed after treatment of clinical symptoms and signs, blood Pressure, heart rate and early kidney damage in laboratory indicators:urinary MAlb,urinaryβ2-MG,urinary NAG and so on, after the end of treatment, all the information entered into the computer, using statistical procedures SPSS.Results:Blood Pressure after treatment showed that the treatment group compound yibazhen capsules Symptom score was significantly lower than the control group and there is significant difference (P<0.01). In addition, the treatment group,urine NAG,β2-MG than those in Pre-treatment has declined significantly (P<0.01) than before treatment; mAlb urine decreased significantly (P<0.05) control group, urine NAG,β2-MG after treatment than before treatment decreased (P<0.05).Comparison of the two groups after treatment, the treatment group decreasedβ2-MG and there is significant difference in the control group (P<0.05).Conclusion:Using compound yibazhen capsules on the basis of felodipine and enalapril is superior to using felodipine and enalapril to meet the blood pressure standards in improvement of symptoms, urine MALB, urineβ2-MG and Urinary NAG. It's concluded that Chinese medicine has an advantage in Renal Protection.