| [Background and objective] Ulcerative colitis(UC) is a chronic inflammatory disease of the colon and rectum. Its etiology and pathogenesis is not entirely clear yet. Immune factors, genetic factors and environmental factors are possibly risk factors. UC was longly considered a diseases major in western countries. South europe and North America have a higher prevalence. After World WarⅡthe incidence rate increased significantly. In recent years, the prevalence has stabilized and maintained at a high level. Its incidence rate in Asia has been judged to be low, but many studies have shown that the incidence of UC in Asia in the past 30 years was gradually increasing. The causes of this is also not clear. May be it can be ascribed to the elevation of people's health awareness and the development of medical science. A lot of people think it's due to the development of economic and living standards and the westernization of lifestyles. The most convincing evidence is that the incidence rate of UC of Asian immigrants in western countries has rised to the level of western countries. Although the incidence of China gradualy increases, the studies on UC is relatively few, and the pathogenesis, clinical features and treatment of chinese patients may be different with the west. These aspects need further study.【Methods】All 60 cases were presented between 2010-2011 in Qilu Hospital and were diagnosed with ulcerative colitis. The epidemiological data, clinical presentation, laboratory tests, endoscopic features and treatment methods of the patients were analysised.【Results】The patients aged from 12 to 80 years old with mean age 45.82±15.66. The peak age of prevalence is 40-50 years old. Male to female ratio was 1.22/1. The average age of male patients is 41.4±16.8 and female 51.2±12.5 which are significantly different (p<0.01). The average duration of male patients was 39.8±67.1 months, women 41.9±68.7 months, the difference is statistically significant (p<0.01). The ratio of urban patients and rural patients was 2/1. Among the patients are 5 who smoke (8.3%), which is lower than the smoking rate in Shandong Province 33.91%(p<0.01). The main clinical manifestations are diarrhea, pus and blood stools, abdominal pain, tenesmus and fever. A few manifested with extraintestinal manifestations such as autoimmune arthritis or PBC. Some patients manifested with lower HGB and ALB, higher ESR and CRP. Of the patients 33.3%were early onset,63.3%were chronic relapsing,1.7%were chronic persistent andl.7%were acute fulminant. Of the patients,18.3%were proctitis,16.7%were proctosigmoiditis,25%were leftside colitis,35%were pancolitis,3.3% wereregional colitis. The common manifestations of UC are congestion and edema, erosion, ulcer, crisp and easily bleeding, mucosal grainy and pseudopolyps. Rare manifestations are stegnosis, disappeared of haustra of colon, and mucosal bridge. Treatment methods includs SASP (86.7%), corticosteroids(63.3%), probiotics (76.7%) and enema treatment (50%). 6.7%underwent surgery.1 case of poor response to conventional treatment improved after application of the infliximab.[Conclusions] The peak age of ulcerative colitis is 40-50 years old, males are easier to get UC. The mean age when male get UC is earlier than female and the course is shorter. Urban patients are more than rural patients. Smoking is a protective factor for ulcerative colitis. The main clinical manifestations of UC are diarrhea, pus and blood stools, abdominal pain, tenesmus and fever with higher ESR and CRP and lower HGB and ALB. The common performance under endoscope are congestion and edema, erosion, ulcers, crisp and easily mucosal bleeding. The treatment methods includ SASP, corticosteroids, probiotics, enema treatment and surgery. Combining using SASP and enema treatment is more effective than using SASP alone. |
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