The Clinical Research Of Treatment Of Kuleqing Tang In Nonalcoholic Steatohepatitis

Background:Non-alcoholic steatohepatitis(NASH) is one of the most commonly seen hepatopathy in western countries. While in China,with the improvement of living standard and the increasing in morbidity of the rich people's diseases like diabetes,hyperlipidemia,hypertension,coronary heart disease, NASH is becoming one of the primary causes to the rise of hepatogenic aminotransferase lacking of certain effective medicine currently and to cryptogenic cirrhosis. Kuleqing,based upon the experience of professor Zhou Zhongying a famous expert devoting his whole life to Chinese medicine,proceeding from the basic pathogenesis of deficiency of liver and kidney as well as phlegm accumulating with stagnation',combining the domestic and overseas research achievements,is expected to be an effective patent herbal medicine for NASH. After the preliminary observation, we find its multiple roles in protecting liver-cell and reducing aminotransferase,adjusting the lipidemia and blood glucose,lowering down the lipid content in the liver,reversing liver fibrosis and early cirrhosis.Objective:to further test and verify the clinical effect of Kuleqing on NASH and to observe its safety,and all in all,to provide an effective medicine for the treatment of NASH.Method:we select 40 qualified cases and divide into treatment group(with Kuleqing) and control group(with Essentiale) randomly.we set 3 months as a therapeutic course and monitor the biological indicator as ALT,AST,TBIL,GGT,AKP and also the infiltrating degree of lipid in the liver as well as relevant safety indicator.Then, we do the statistic analysis by SPSS 10.0 and objectively evaluate its efficiency and safety.Result:Kuleqing can not only improve the clinical manifestations and signs like fatigue,indigestion,dull pain in the liver area,hepatosplenomegaly but also the biological indicator markedly,lower down the level of lipid infiltration and BMI.we haven't found any adverse effect from the blood routine test,urine routine test and renal function.Conclusion:it is true a effective medicine for NASH and deserve further researches.