| Objective: This research is designed to study the clinical effect of Yangganjieyu particles in treating on the non-alcoholic steatohepatitis(depressed liver and deficient spleen coupled with stasis syndrome).In this article,we study the problem of NASH implementation in private good economies with single-peaked,single-plateaued,and single-dipped preferences in the presence of at least one minimally honest agent.We prove that all solutions of the problem of fair division satisfying unanimity can be implemented in NASH equilibria as long as there are at least three agents participating in the mechanism(game form).)The changes in nonalcoholic fatty liver disease(NASH)range over a wide spectrum,extending from steatosis to steatohepatitis(NASH).However,it has remained difficult to differentiate between NASH and nonprogressive NASH by clinical examination.We investigated the interrelationships between serum high-sensitivity C-reactive protein(hs-CRP)and the pathogenesis and progression of NASH.To justify this result,we provide a list of solutions which violate the condition of no-veto power.Yangganjieyu particles is composed mainly of modified Danzhixiaoyao powder,the research interest mainly lies in digestive system disease of internal medicine of traditional Chinese medicine.In this paper,the clinical effect of Yangganjieyu particles in inhibiting non-alcoholic steatohepatitis(NASH)was observed to validate the advantages and features of traditional Chinese medicine in treating NASH,in order to make further contributions to further standardization and exploration of non-alcoholic steatohepatitis.Method: According to the bringing,excluding criteria and seceding request,put filtrating out to identify patients from Changchun University of Traditional Chinese Medicine Auxiliary Hospital of liver,spleen and stomach diseases department outpatient service and cure district,randomly percentages divided into therapy group and contrast group.This research chose a total of 72 patients who were diagnosed by western medicine as NASH and by Chinese medicine as liver fixity(depressed liver and deficient spleen coupled with stasis syndrome)and admitted by the outpatient service of affiliated hospital of Changchun University of TCM,and they were divided into treatment group and control group using the method of random number table.Treatment group: Yangganjieyu particles,1 bag/time,postprandial 30 min,three times a day,administered after dissolved in warm boiled water.Course of treatment: 24 weeks.Control group: on the basis of fundamental treatment,essential phospholipid(polyenoid phosphatidylcholine capsule)was administered at 456mg/time(2 capsules),postprandial 30 min,three times a day,oral.Course of treatment: 24 weeks.All the primary,secondary symptoms and CT reading of liver,gallbladder and spleen of all the patients included into the group before and after treatment were observed and summarized to come to a conclusion of safety and effectiveness of Yangganjieyu particle in treating NASH(depressed liver and deficient spleen coupled with stasis syndrome).Result: over 24 weeks of clinical observation and recording,the statistical software SPSS19.0 was used to analyze the observational indexes and curative effect criteria of two groups of patient before and after treatment,some conclusions were drawn as follows: 1)basic condition comparison: according to statistical analysis,There was no statistically significant difference in sex,age,course of disease,degree of illness between the two groups(P>0.05),showing a comparability.2)comparison of symptom and curative effect: intra-group comparison was done to the two groups after treatment,the difference was significant(P<0.01),the patients in the treatment group had their lateral thorax pain,feebleness,agitation and irritability improved as compared to before,the different between it and control group was relatively significant(P<0.05),however,there was no recognizable difference in nausea belching,inappetence and loose stool discomfort between the two groups(P>0.05).Comparison of liver function improvement: intra-group comparison was conducted to the two groups after treatment,the differences in results were all significant(P<0.01);according to an inter-group comparison between the treatment and control group,the post-treatment curative effect of the former was clearly better than that of the latter(P<0.01).after being treated,the two groups of patient were compared with each other in terms of liver/spleen CT reading,the total effective rate of treatment and control group was respectively 88.57% and 65.71%.Through a statistical treatment and analysis,the results were significantly different(P<0.05).Comparison of total points of syndrome: according to the evaluation criteria for TCM syndrome,the total effective rate of treatment and control group was respectively 91.43% and 74.29%.Through a statistical treatment and analysis,the results regarding the curative effect on syndrome of two groups were significantly different(P<0.05).and the treatment group was superior to control group in curative effect.Rank sum test,the point of post-treatment syndrome among the 30 patients in treatment group was 3.182±0.422;the point of post-treatment syndrome among the 30 patients in control group was 10.593±0.763.According to t-test,t=-9.994,p=0.01,p<0.05.There were significant statistical differences between the treatment group and control group after treatment(P<0.05).The overall efficacy of the treatment group was better than that of the control group.Observation of safety: during the test,one patient in the treatment was found to have a diarrhea,which was tolerable,and improved without any treatment,no other symptoms.In the control group,2 patients were found to have sour regurgitation,one patient was found to have poor appetite,which were all tolerable and automatically improved without any treatment.All the routine examinations,blood routine,urine routine,stool routine and kidney function test that the subjects underwent before and after medication reported normal results,suggesting that,the medicine used by the treatment group,Yangganjieyu particles,was safe.Conclusion: From the data obtained above,it is shown that all the patients in the treatment of Yangganjieyu particles in treating NASH(depressed liver and deficient spleen coupled with stasis syndrome),it was revealed by the test and study that,both the clinical symptoms of patient and their laboratory test results can be remitted by applying the method of soothing liver and strengthening spleen to treat NASH(depressed liver and deficient spleen coupled with stasis syndrome),especially in the aspect of improving lateral thorax pain,feebleness,agitation and irritability.In contrast to the treatment of NASH by(polyenoid phosphatidylcholine capsule),Yangganjieyu particles has a significant advantage in remitting the symptoms,improving liver enzyme and regulating the CT ratio of liver/spleen. |
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