Clinical Research Of Zijinpi San On The Treatment Of The Swelling Resulting From The Calcareous Fracture In The Early Stage

Object:Through the clinical research that Zijinpi San combining Sodium Aescinate on the treatment of the swelling resulting from the calcareous fracture, this study evaluates the curative effect of Zijinpi San for external application and the value for it.And it provides science basis for its clinical application.Methods:There were 51 patients of 2009～2011 from 17～52 years old. Finally, there were 44 patients up to the standard which for clinical testing, and 33.20 in average, who were collected from the orthopedic department of Affiliated Hospitals of Putian Institute in this group, in which 30 patients were male and 14 were female. These patients were clearly diagnosed as calcaneal fractures and they selected the conservative treatment. All the patients took participated in the test on the basis of the random result; the patients were divided into two groups, the experimental group 26 cases and the control group 18 cases. The experimental group:20mg Sodium Aescinate joining 100ml NS for intravenous infusion treated the swelling once a day. At the same time, Zijinpi San was applied externally at local swollen skin. The control group:20mg Sodium Aescinate joining 100ml NS for intravenous infusion treated the swelling once a day. A course of treatment was 10 days, and the general treatment period was one course of treatment. And observe and record the degree of the limb swelling every 12 hours. Through comparing the new observation with last one, record the time when swelling in the most severe case and the time when the swollen skin appeared wrinkly. Measure and record the circumference of both the affected and the contralateral side everyday after treatment. (The circumference method is shown in Figure 3.)Result:Only one patient had drugreaction and all patients had no other adverse reactions in the two groups. To the time when swelling in the most severe case, the time when the swollen skin appear wrinkly and the degree of pain and skin ecchymosis, there were significant statistical differences (P<0.05) between the two groups. The degree of the limb swelling on day 3,6 and 10 after treatment was significant statistical differences too.Conclusion:The research showed that Zijinpi San for external application is highly positive for relieving the swelling resulting from the calcareous fracture in the early stage. It can relieve the pain and swelling in the shortest time.