Clinical Efficacy On Treating IgA Nephropathy With Zini-Shenyan Decoction

Objective:To observe the clinical effects of the Zini Shenyan decoction on IgA-nephropathy (syndrome deficiency of Qi and Yin) urine erythrocyte count, urinary albumin/creatinine, urine protein of 24 hours, serum immunoglobulin IgA, complement C3 and the clinical symptom score of TCM.Materials and methods:60 IgAN patients with different degree gross hematuria and proteinuria were chosen and divided into contrast group (30 cases) and treatment group (30 cases) at random. Patients of contrast group took the modern medicine conventional therapy and Benazepril. Patients of treatment group took the Zini Shenyan decoction and add modern medicine conventional therapy.Both groups were treated for 3 months. Before and after therapy, test the change of urine erythrocyte count, urinary albumin/creatinine, urine protein of 24 hours, serum immunoglobulin IgA, complement C3 and the clinical symptom score of TCM.Results:(1) Zini Shenyan decoction on the treatment of urine erythrocyte count:The treatment group could remarkably reduce the urine erythrocyte count. It was obviously superior to the contrast group(P<0.05). (2) Zini Shenyan decoction on the treatment of urinary albumin/creatinine and urine protein of 24 hours:They could be significantly decreased in the two groups.There was no significant difference in efficacy(P>0.05).(3)Zini Shenyan decoction on the treatment of serum immunoglobulin IgA and complement C3:It is no significant changes in both groups before and after treatment. There was no significant difference in efficacy(P>0.05). (4) Zini Shenyan decoction on the treatment of the clinical symptom score of TCM:The TCM symptoms had been distinctly improved after treatment in the two groups. There was distinctive difference between the two groups, and the treatment group was better than the control group(P<0.05). (5) The clinical effects of treatment group was obviously superior to those of contrast group(P<0.05).Conclusion:Zini Shenyan decoction can remarkably reduce the urine erythrocyte count and urinary albumin/creatinine and urine protein of 24 hours,so it can reduce the damage of kidney and delay the deterioration of kidney disease.It also can improve clinical symptoms of the patients and improve their quality of life.