Clinical Observation On The Effect Of Modified Shenqi Dihuang Decoction On Proteinuria And Hematuria Of IgA Nephropathy With Deficiency Of Qi And Yin

Objective: To explore the effect of Jiawei Shenqi Dihuang Decoction on proteinuria and hematuria in patients with IgA nephropathy with deficiency of both qi and yin,and to provide evidence for the prevention and treatment of IgA nephropathy with clinical Chinese medicine.Methods: From January 1,2020 to December 31,2020,60 patients with IgA nephropathy who had urine protein quantification of 1-2 g/d in the outpatient and inpatient clinics of the Department of Nephrology of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine were selected and randomly divided.For the treatment group and the control group.The control group was treated with perindopril tertbutylamine tablets and routine basic treatments such as high-quality protein diet,blood pressure control,and lipid regulation.The treatment group was treated with Jiawei Shenqi Dihuang Decoction in combination with the treatment of the control group.Both groups were treated with corresponding treatment for 3 months.24-hour urine protein quantification,urine red blood cell count,blood creatinine,urea nitrogen,and TCM syndrome scores were observed and analyzed before and after treatment.Results:(1)Effect on 24-hour urine protein quantification: After 3months of treatment,treatment group: 24-hour urine protein quantification average value of 1495.83 ± 289.08 mg/24 h before treatment,24-hour urine protein quantification average value of 934.06 after treatment ± 245.95mg/24h;24-hour urine protein quantitative comparison before and after treatment P < 0.05,the difference is statistically significant.Control group: 24-hour urine protein quantitative average value 1504.73 ± 220.21mg/24 h before treatment,24-hour urine protein quantitative average value 960.60±201.10mg/24 h after treatment;24-hour urine protein quantitative comparison before and after treatment P<0.05,which The difference was statistically significant.The comparison between the two groups after treatment was P>0.05,and the difference was not statistically significant.(2)Effect on urine red blood cell count: the two groups were treated for 3 months as follows: Treatment group: the average urine red blood cell count before treatment was 8.37 ± 2.44 cells/ μ L,and the average urine red blood cell count after treatment was 4.47±2.63 cells/μL,the comparison of urine red blood cell counts in the treatment group before and after treatment P < 0.05,the difference was statistically significant.Control group: The average urinary red blood cell count before treatment was 9.67 ± 2.70/ μ L,the average urinary red blood cell count after treatment was 6.37±2.04/μL,the comparison of the urinary red blood cell count before and after treatment in the control group was P<0.05,the difference was statistically significant significance.After treatment,the comparison between the two groups was P<0.05,and the difference was statistically significant.(3)Effect on creatinine: After 3 months of treatment in both groups,the comparison of creatinine in the treatment group before and after treatment P>0.05,the difference was not statistically significant;the comparison of creatinine in the control group before and after treatment P>0.05,The difference was not statistically significant.(4)Effect on urea nitrogen: After 3 months of treatment in both groups,the comparison of urea nitrogen in the treatment group before and after treatment P>0.05,the difference was not statistically significant;the comparison of urea nitrogen in the control group before and after treatment P>0.05,the difference is not statistically significant.(5)Influence on TCM syndrome: the comparison of TCM syndrome scores before and after treatment in the treatment group P<0.05,the difference is statistically significant;the comparison of TCM syndrome scores before and after treatment in the control group P<0.05,the difference is statistically significant;After treatment,the comparison of TCM syndrome scores between groups was P<0.05,the difference was statistically significant,and the treatment group was better than the control group.(6)Impact on the efficacy of TCM syndrome: the effective rate of the treatment group was 93.3%,and the effective rate of the control group was 70.0%.The comparison of the efficacy of TCM syndrome between the two groups after treatment,P<0.05,the difference was statistically significant,the treatment group was excellent In the control group.(7)Impact on clinical efficacy: the effective rate of the treatment group was 86.6%,and the effective rate of the control group was 66.6%.The clinical efficacy comparison between the two groups after treatment was P<0.05,the difference was statistically significant,and the treatment group was better than the control group.Conclusion:(1)Modified Shenqi Dihuang Decoction can reduce proteinuria and urinary red blood cell count in patients with IgA nephropathy with deficiency of both qi and yin,and delay the progression of kidney disease.(2)Modified Shenqi Dihuang Decoction can reduce the patient’s TCM syndrome score,improve the TCM clinical symptoms of patients with IgA nephropathy with deficiency of both qi and yin,and improve the efficacy and clinical efficacy of TCM symptoms.