The Clinical Study Of PenQiangYan Granule On Treating Chronic Pelvic Inflammatory Disease And The Effect On Inflammatory Related Cell Apoptosis Of The Experimental

Objective: Through the observation pelvic inflammatory disease pellet treatment blood stasis concurrently kidney empty chronic pelvic inflammatory disease's clinical curative effect and the change which perishes weakly to the chronic pelvic inflammatory disease model big mouse cell, discusses the pelvic inflammatory disease pellet treatment chronic pelvic inflammatory disease (CPID) the cell perishes weakly the mechanism, provides the basis for the clinical practice.Method: 60 cases of chronic pelvic inflammatory disease were divided into two groups randomly: Pen Qiangyan Granule treatment group and Pen Yanjing Granule control group, each group of 30 examples. Female Wistar rats were used and the CPID model was established with mixed bacteria injection combined with mechanic injury. Sixty rats were randomly divided into seven groups. After the histomorphological changes of the rats' uteri were observed, Immunity set the expression that turn a S-P law to examine each big rat womb organization Caspase-3;Converse to record-the polymerization Mao chain reaction the law(RT-PCR) examine the big rat womb organization Fas/FasLmRNA and the expression of the p 53 mRNAs.Result: The clinical observation result suggests that more showing of the treatment set and matched control comprehensive clinical curative effect rate, always efficient relatively has polar show Zhao discrepancy(P<0.01), treatment set curative effect better than matched control;Two sets of Chinese medicine certificates wait more showing of the curative effect rate, always efficient compare, all have already shown Zhao discrepancy(P<0.05), the treatment set curative effect surpasses a matched control.After curing two sets of sufferers comprehensive integral, Chinese medicine symptom integral, partial body's advertising for integral a little bit all has already shown Zhao discrepancy(P<0.05), the treatment set obviously surpasses a matched control. Chronic basin chamber fire pattern big rat womb in the middle of the organization the expression of Caspase-3, Fas/FasLmRNA and the p 53 mRNAs more normal matched control big rat scale - up, the discrepancy all has very show Zhao.(P<0.01) After medicine interferes, each treatment set big rat womb organization amid expression and pattern set vis - a - vis of Caspase-3, Fas/FasLmRNA and the p 53 mRNAs all enhancement.(P<0.05)In addition to Caspase-3, the basin chamber blazes all obviously better than basin of the action of grain big amount of agent set burning net set.(P<0.01)Basin chamber burning each amount of agent of grain set womb organization FasmRNA and FasLmRNA voice a coefficient of correlation to 0.894 and present to show the Zhao positive correlation.(P<0.01).Conclusions: Basin chamber fire the grain treatment blood Yu and kidney falsely the type chronic basin chamber fire contain better clinical curative effect and pass to strengthen chronic basin a chamber fire pattern big rat womb in the middle of the organization the expression of related beacon of Diao Wu, induce to blaze cell Diao Wu, repress to blaze a cell growth, ease to blaze disease reaction thus.