AIDS Clinical Data Analysis And The Expression Levels Of IL-12, ICAM-1 In AIDS Combined Oral Candidiasis

Objective:By analyzing 307 cases of human immunodeficiency virus (HIV) infection/AIDS incidence in patients with the clinical data to understand the the relevant circumstances in HIV/AIDS patients.And to investigate the consolidation of acquired immunodeficiency syndrome patients with oral candidiasis, peripheral serum interleukin-12 and intercellular adhesion molecule-1 expression, in order to understand IL-12 and ICAM-1 and oral candidiasis in HIV pathogenesis.Methods:(1) Collection of Changsha City Public Health Center for treatment from January 2009 to September 2010 confirmed HIV/AIDS patients as the research object, statistical analysis on the general sociological features, infection routes, the main symptoms, CD4 T lymphocyte count and other clinical data.(2) ELISA was used to detect the expression of IL-12 and ICAM-1 in each peripheral blood plasma of AIDS patients and healty people.Results:1-. Analysis of clinical data of 307 patients showed:patients were mainly 21-50 years old, secondary education the following men,who is about 2.7 times that of female patients; the main routes of infection is sexually transmitted; fever and oral candidiasis are the major symptoms; CD4 T lymphocyte count in AIDS patients with combined oral candidiasis is significantly lower than who without combined oral candidiasis.2,IL-12 and ICAM-1 expression results showed:IL-12 and ICAM-1 were expressed in all plasma;when AIDS patients without combined oral candidiasis,IL-12 was significantly decreased and ICAM-1 was ;and in AIDS patients' plasma with combined oral candidiasis,IL-12 and ICAM-1 both were significantly increased.Conclusions:(1) patients were mainly 21-50 years old, less educated and have unsafe sex men.(2) fever and oral candidiasis are the major symptoms.(3) the emergence of oral candidiasis is a sign of AIDS in the late course of the disease into a poor prognosis.(4) IL-12 in the combined oral candidiasis expressed as overexpression.(5) ICAM-1 in peripheral blood of AIDS patients were shown to be over expressed, especially significant in the combined oral candidiasis.