Liaoning, Jilin And North Korea Ginseng Comparative Study Of The Influence Of Cellular Immunity In Mice

Purpose:To scientifically compare the effect of ginseng from different regions on Cellulate Immunity Medicine Effect, like activity of lymphocyte transformation, content of IL-2 in Seru and Activity of Natural Killer Cell, as to identify the relationship between the origin of ginseng and cellulate immunity medicine effect, which can provide reliable statistics to the development of Liaoning economy and to establish the Brand of"Liaoning Ginseng".Material and method:Select 80 healthy female rats, which are divided into eight groups. Each group is caged by normal feeding, among which A1: Normal Comparison Group; A2: Liaoning Ginseng Group; A3: Jilin Ginseng Group; A4: Korean Ginseng Group; B1: Inhibited Immunity Comparison Group; B2: Inhibited Immunity Liaoning Ginseng Group; B3: Inhibited Immunity Liaoning Ginseng Group; B4: Inhibited Immunity Korean Ginseng Group. For the rats in Group B, the Inhibited Immunity Model is made by the model-making method which is recognized internationally, i.e. to inject cyclophosphamide to the rats'belly 80 mg/kg, once the other day, four times in total. When model-making is successful for Inhibited Immunity Group, lavage rats stomach who are in A2, A3, A4, B2, B3, B4 using ginseng water; Lavage rats stomach who are in A1 and B1 using Brine, 0.4 ml/one rat, once per day, continuously, twelve days later, examine the index of Activity of lymphocyte transformation, IL-2 content in Seru and Activity of Natural Killer Cell.Results:1 All the ginseng from the three regions can increase the spleen index of normal rats and Inherit Immunity Rats(p<0.05); and increase the spleen index of Inherit Immunity Rats to a normal level(p>0.05).There is no comparing statistics meaning of the impact on spleen index for the normal rats and inherit immunity rats by ginseng from different regions(p>0.05). 2 All the ginseng from the three regions can accelerate the Lymphocyte Transformation Activity for both Normal rats and Inherit Immunity rats(p<0.05),There is no comparing statistics meaning of the impact on Lymphocyte Transformation Activity for the normal rats and inherit immunity rats by ginseng from different regions(p>0.05); Yet Liaoning Ginseng can increase the Lymphocyte Transformation Activity of Inherit Immunity Rats to a normal level(p>0.05).3 All the ginseng from the three regions can accelerate the content increase of IL-2 in Seru for both Normal rats and Inherit Immunity rats(p<0.05); and increase the IL-2 content in seru of Inherit Immunity Rats to a normal level (p>0.05),. Among the ginseng from the three regions, Liaoning ginseng can better increase the IL-2 content in Seru for both Normal Rats and Inherit Immunity Rats (p<0.05).4 All the ginseng from the three regions can accelerate the increase of NK activity for both Normal rats and Inherit Immunity Rats (p<0.05) , and increase the NK cell Activity of Inherit Immunity Rats to a normal level (p>0.05),.There is no comparing statistics meaning of the impact on NK Activity for the normal rats and inherit immunity rats by ginseng from different regions(p>0.05).Conclusion:1 All the ginseng from the three regions can accelerate the spleen index and the NK cell activity for both Normal rats and Inherit Immunity rats, and can increase them to a normal level.2 All the ginseng from the three regions can accelerate the Lymphocyte Transformation Activity for both Normal rats and Inherit Immunity rats, Liaoning ginseng can increase the Lymphocyte Transformation Activity of Inherit Immunity rats to a normal level, with no difference among the ginseng from the three region.3. All the ginseng from the three regions can increase the content of IL-2 in Seru for both Normal rats and Inherit Immunity rats, and can increase the IL-2 in Seru of inherit immunity rats to a normal level. The impact of Liaoning ginseng on IL-2 in Seru of normal rats and inherit immunity rats are stronger than that of Jilin and Korea.