Liver Stagnation Particles Combined Stress Depressive Behavior In Rats And Liver Function Of Chronic Liver Injury

Objective :In order to investigate the effects of Yanggan Jieyu Keli to the rat model of chronic liver injury and separate bree with CUMS on behaviors,hypothalamic neurotran -smitter . To discuss the mechanism of the Yanggan Jieyu Keli.Methods:1.Dividatur the rats into 8 groups randamly:blank array,chronic hepatic injury and stress depression model array,chronic hepatic injury model array ,Yigan Yiqi Jieyu Keli array,Fluoxetine Hydrochloride Capsules array,the diminutive,midst,large dose of Yanggan Jieyu Keli.2.The model was established by subcutaneous injection of carbon tetrachloride and separate bree with CUMS. The rats' weight, the Open-field test,sucrose intake, monoamine neurotransmitters in hypothalamus of rats were measured during the experiment,and liver pathology was observed.Results:Yanggan Jieyu Keli can improve the rats' weight, the Open-field test,sucro seintake, monoamine neurotransmitters in hypothalamus and liver pathology.Conclusion:We can produce the chronic liver injury and separate bree with CUMS model of rats successfully by subcutaneous injection of carbon tetrachloride and separate bree with CUMS. 2.The consequence to the research manifest that:Yanggan Jieyu Keli can improve the weight, the Open-field test,sucro seintake , monoamine neurotransmitters in hypothalamus,liver pathobiology of the rats in a certain extent. On the whole, it is effective than the positive control group. 3. Yanggan Jieyu Keli had the effect of liver protective and antidepressant, and is worthy of further study and development.