| Objective:The paper investigated the laws of herbal prescriptions in the treatment of Diabetic Nephropathy (DN) in Traditional Chinese Medicine (TCM) to provide the basis for TCM treatment in the disease and the reliable reference for the clinical treatment and clinical research.Method:The paper collected literatures which include not only western medicine diagnosis of DN and also TCM treatment from domestic publications of TCM and integrated TCM and western medicine from 2000 to 2010. The paper established relevant databases after screening, data entry and specifications and analyzed the drug application times, frequency, type of medicine and performance (taste, and meridian) of TCM treatment of DN through the statistical data in the database, summarizing the drug law in the medical treatment of this disease.Results:1. This study included 196 Chinese herbal formula of DN treatment, involving 187 flavors, and the times of total use was 1955. Among them, the drug which have a high frequency were 21 flavors and they showed 1150 times, accounting for 58.8% of the total times. 43 flavors were more than the average frequency of the drug. Summary of the five most common use drugs of the medical treatment are as following: Astragalus (71.94%), Salvia (50.51%), Dogwood (46.43%), Poria (43.37%) and Yam (41.84%).2. The tonic drugs (35.84%), promoting blood circulation by removing blood stasis drugs (16.61%), antipyretics drugs (11.19%), dampness-clearing drugs (10.37%) and arresting-discharge drugs (8.10%) shared larger proportion of a total 1589 times in drug treatment of DN, whose cumulative frequency is up to 81.95%. The two kinds of significant medicine property are cold and warm and the both proportion were 71.91% accumulatively. The three kinds of herbal taste of sweet, bitter and Xin, are most commonly used whose accumulative frequency is 83.86%. Drugs were classified by meridian, the top five are the liver, the kidney, the lung, the spleen and the stomach, the cumulative frequency of which was 73.08%. Classified by the times showed in it, the top five are the liver, the spleen, the kidney, the heart and the lung, cumulative frequency of which up to 78.73%.Conclusion:1.Based on the analysis of DN prescription of Chinese medicine treatment, Astragalus and Salvia are most commonly used. The most frequently used drug classes are tonic drugs, promoting blood circulation by removing blood stasis drugs, antipyretic drugs and dampness-clearing drugs. The property of herbs is mainly cold and warm, the tastes mainly sweet, bitter and Xin, meridians mainly the liver, the kidney and the spleen.2. All in all, drugs chiefly used are tonic for liver, kidney and spleen, supplementing qi and nourishing yin, promoting blood circulation by removing blood stasis ,inducing diuresis to alleviate edema and removing dampness and phlegm. All this reflects that the etiology and pathogenesis features of the DN are The vacuity and deficiency-excess complication. Tonifying is as the main application rule and removing the evil meantime is the laws of the DN drug use. |
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