Discussion On The Prescription Of The Ancient Medicine Of Diabetic Nephropathy And The Prescription Of Astragalus Compound

Diabetic nephropathy secondary to Diabetic mellitus,It is one of the major complications of Diabetic mellitus.also the leading cause of end-stage renal disease with extremely high fatality rate.The incidence of this disease is increasing year by year in our country.And the drugs and means of preventing and controlling the development of the disease have not been effective.To summarize the unique experience of TCM in the prevention and treatment of diabetic nephropathy,It has important clinical significance.This study is divided into two parts.The first part is to retrieve the ancient medical records,to explore the law of drug use in ancient books.The second part is the selection of milkvetch root in ancient books,Conduct modern synergy analysis.Part I:study on the ancient literature of diabetic nephropathy.Objective:To comprehensively retrieve the medical treatment of diabetic nephropathy in ancient books,Establish adatabase,Analysis high frequency drug use,refining core medicine and core prescription,summarize treatment experience.Methods:In order to retrieve the ancient books with greater contribution in each period by the Chinese medical dictionary,The key words are "kidney elimination","elimination of kidney" and "elimination",etc.Screening formulas according to inclusion criteria and exclusion criteria,Canonical data,enter the Excel sheet.SPSS20.0 was used for frequency and cluster analysis of data.Results:1.In ancient 203 prescriptions for diabetic nephropathy,The drug and drug categories with high frequency were mainly included:eliminating dampness and diuresis Poria cocos,Astringent medicine cornel,keel,benefiting qi drug milkvetch root,ginseng,nourish yin drug dwarf lilyturf,tonifying yang drug cistanche,velvet antler,replenishing blood drug Rehmannia glutinosa,warming interior drug cinnamon,clearing heat drug rhizoma coptidis,strengthening resistance to relieve superficies syndrome drug kudzu root,expelling phlegm drug almond.2.The prescription involves the drug 189 taste.The proportion of sweet and warm was the largest.They were 49.47% and 42.61%respectively.The proportion of pungent and cool is the smallest,It was 7.52% and 1.88% respectively.3.The core and representative prescriptions are respectively:nourishing yin and clearing heat,invigorating kidney qi,invigorating spleen for diuresis and invigorating kidney for consolidating semen.The core prescription:White tiger ginseng soup,shenling baizhu powder,jisheng shenqi pills and mantis egg-case scattered.The second part:the study on the prevention and treatment of diabetic nephropathy by huangqi compound.Objective:Through studying the modern literature of astragalus compound,explore the rule of astragalus group.Guide clinical medication,provide theoretical basis for new drug development.Methods:It is mainly based on the Chinese database CNKI.Wanfang Date and VIP Chinese database supplement.The topic is diabetic nephropathy.The full text contains "astragalus" as the search term.The second time retrieval word is "Traditional Chinese medicine","traditional Chinese medicine","TCM compound","Chinese medicine","Chinese medicine","self-intended party",Retrieve relevant literature from 2007 to 2017.Screening formulas according to inclusion criteria and exclusion criteria,Canonical data,enter the Excel sheet.SPSS20.0 was used for frequency and correlation analysis of data.Results:1.102 Chinese Astragalus compound 149 flavors,It is mainly based on promoting blood circulation for removing blood stasis,astringing yin and consolidation of superficies,eliminating dampness and diuresis.The core compatibility drugs with astragalus is Salvia miltiorrhiza,Sanqi,dogwood,yellow,poria,rhubarb,leech.2.Core portfolio depth analysis,get four core prescription,be chiefly used in syndrome of deficiency of heart qi and blood stasis,syndrome of dampness stagnancy due to spleen deficiency and syndrome of non-consolidation of kidney qi.Conclusion:1.Diabetic nephropathy is based on "deficiency syndrome",The treatment is mainly to supplement the deficiency.The use of the higher frequency is milkvetch root2.Modern astragalus compound,Core drugs is milkvetch root compatibility activating blood circulation.3.The treatment of invigorated blood and blood stasis can be achieved by supplementing qi drug.There are many records in ancient books,activating blood circulation Less application.To study the relationship between "blood stasis" and the pathogenesis of this disease,provide theoretical basis for new drug development.